DARPA’s THoR grant aims to discover host resilience mechanisms against infectious diseases to develop interventions for human health. This grant seeks novel technologies to understand how some hosts are resilient to infections, with a focus on identifying biological relationships underlying tolerance. The program consists of three Technical Areas to study resilient animal hosts, uncover biological tolerance mechanisms, and develop interventions for reducing morbidity and mortality. Applications should focus on prospective animal studies and analysis of pre-clinical and human clinical data. Closing date for submissions is Jun 09, 2015.
Opportunity ID: 275568
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-15-21 |
| Funding Opportunity Title: | Technologies for Host Resilience (THoR) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 5 |
| Posted Date: | Mar 31, 2015 |
| Last Updated Date: | May 18, 2015 |
| Original Closing Date for Applications: | May 19, 2015 |
| Current Closing Date for Applications: | Jun 09, 2015 4:00 pm eastern standard time |
| Archive Date: | Sep 30, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets. |
| Link to Additional Information: | DARPA-BAA-15-21 at FedBizOpps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
COL Matthew Hepburn, M.D.
Program Manager Biological Technologies Office Email:DARPA-BAA-15-21@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| The purpose of Modification #2 to DARPA-BAA-15-21, the Technologies for Host Resilience (THoR) Broad Agency Announcement, is to change the listed items that count towards the page limit.
Section 4.3.1 is updated as follows: The maximum page count for Volume 1 is 20 pages (8.5̋ x 11̋ paper, 11 point Times New Roman font, single line spacing), including all figures, tables and charts but not including the cover sheet, table of contents, statement of work, schedule and milestones, cost summary table, or appendices. A submission letter is optional and is not included in the page count. See full BAA package Amendment #2, Section 4.3.1.1 for incorporated changes. |
May 18, 2015 | |
| DARPA-BAA-15-21 Modification #1 revises the proposal due date to June 9, 2015 4:00 pm and shows Figure 1 that did not correctly display in the original BAA package. | May 18, 2015 | |
| The Proposal Due Date is changed to June 9, 2015 4:00 pm from May 15, 2015 11:59 pm. Additionally, Section 1.1, page 9, Figure 1 of the BAA package did not display properly so it has been included in the modification attachment. | Apr 24, 2015 | |
| The modification incorporates the cut-off time of 4:00 pm EST for proposal submissions in the | Apr 24, 2015 | |
| Apr 01, 2015 |
DISPLAYING: Synopsis 5
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-15-21 |
| Funding Opportunity Title: | Technologies for Host Resilience (THoR) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 5 |
| Posted Date: | Mar 31, 2015 |
| Last Updated Date: | May 18, 2015 |
| Original Closing Date for Applications: | May 19, 2015 |
| Current Closing Date for Applications: | Jun 09, 2015 4:00 pm eastern standard time |
| Archive Date: | Sep 30, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets. |
| Link to Additional Information: | DARPA-BAA-15-21 at FedBizOpps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
COL Matthew Hepburn, M.D.
Program Manager Biological Technologies Office Email:DARPA-BAA-15-21@darpa.mil |
DISPLAYING: Synopsis 4
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-15-21 |
| Funding Opportunity Title: | Technologies for Host Resilience (THoR) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 4 |
| Posted Date: | May 18, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Jun 09, 2015 4:00 pm eastern standard time |
| Archive Date: | Sep 30, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets. |
| Link to Additional Information: | DARPA-BAA-15-21 at FedBizOpps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
COL Matthew Hepburn, M.D.
Program Manager Biological Technologies Office Email:DARPA-BAA-15-21@darpa.mil |
DISPLAYING: Synopsis 3
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-15-21 |
| Funding Opportunity Title: | Technologies for Host Resilience (THoR) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Apr 24, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | May 19, 2015 4:00 pm eastern standard time |
| Archive Date: | Sep 30, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets. |
| Link to Additional Information: | DARPA-BAA-15-21 at FedBizOpps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
COL Matthew Hepburn, M.D.
Program Manager Biological Technologies Office Email:DARPA-BAA-15-21@darpa.mil |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-15-21 |
| Funding Opportunity Title: | Technologies for Host Resilience (THoR) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Apr 24, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | May 19, 2015 4:00 pm eastern standard time |
| Archive Date: | Sep 30, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets. |
| Link to Additional Information: | DARPA-BAA-15-21 at FedBizOpps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
COL Matthew Hepburn, M.D.
Program Manager Biological Technologies Office Email:DARPA-BAA-15-21@darpa.mil |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-15-21 |
| Funding Opportunity Title: | Technologies for Host Resilience (THoR) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 01, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | May 19, 2015 |
| Archive Date: | Sep 30, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | This program strives to discover host tolerance mechanisms in order to identify a suite of interventions suitable for use in humans to mitigate the deleterious effects of infectious diseases. THoR is seeking novel methods and technologies to discover and understand these responses in hosts that are resilient when exposed to infectious diseases. Specifically, DARPA aims to discover the fundamental biological relationships that underlie host tolerance to infection in animal populations in order to provide the foundational knowledge required to develop interventions for potential transition into clinical use. This program is organized into three Technical Areas (TAs): 1) Identification and characterization of animal hosts with tolerant phenotypes; 2) Discovery of biological mechanisms that underlie tolerance; and 3) Identification of interventions that utilize tolerance mechanisms with the goal of reducing morbidity and mortality due to infection. This BAA will focus specifically on understanding tolerance mechanisms in prospective animal studies in conjunction with the analysis of retrospective pre-clinical and human clinical datasets. |
| Link to Additional Information: | DARPA-BAA-15-21 at FedBizOpps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
COL Matthew Hepburn, M.D.
Program Manager Biological Technologies Office Email:DARPA-BAA-15-21@darpa.mil |
Related Documents
Folder 275568 Full Announcement-1 -> attachment 4 – darpa-baa-15-21 – work breakdown structure template.pdf
Folder 275568 Full Announcement-1 -> attachment 1 – darpa-baa-15-21 – sow template.pdf
Folder 275568 Full Announcement-1 -> darpa-baa-15-21 final pao.pdf
Folder 275568 Full Announcement-1 -> attachment 2 – darpa-baa-15-21 – budget template.pdf
Folder 275568 Full Announcement-1 -> attachment 3 – darpa-baa-15-21 – gantt chart template.pdf
Folder 275568 Full Announcement-2 -> darpa-baa-15-21 thor amendment 2.pdf
Packages
| Agency Contact Information: | COL Matthew Hepburn, M.D. Program Manager Biological Technologies Office Email: DARPA-BAA-15-21@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00215952 | Mar 31, 2015 | May 19, 2015 | View |
Package 1
Mandatory forms
275568 RR_SF424_2_0-2.0.pdf
Optional forms
275568 PerformanceSite_2_0-2.0.pdf
275568 RR_OtherProjectInfo_1_3-1.3.pdf
275568 RR_KeyPersonExpanded_2_0-2.0.pdf
275568 RR_Budget10_1_3-1.3.pdf
275568 RR_SubawardBudget10_30_1_3-1.3.pdf
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