This Department of Defense grant is for establishing a Lung Cancer Biospecimen Resource Network (LCBRN). Its purpose is to provide infrastructure support for a collaborative network across multiple institutions to facilitate the collection, processing, annotation, storage, and distribution of high-quality human lung cancer biospecimens. The LCBRN will comprise a Coordinating Center and at least two Biospecimen Resource Sites, jointly responsible for developing this vital resource. Applicants must demonstrate capabilities in collecting diverse biospecimen types, managing associated data, derivatizing biological molecules, and utilizing state-of-the-art processing technologies. The network must support critical research areas, including improved early detection, screening, understanding molecular mechanisms of cancer development, identifying innovative prevention and treatment strategies, and defining predictive/prognostic markers for treatment response. This initiative aims to significantly advance lung cancer research.
Opportunity ID: 49421
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-09-LCRP-LCBRNA |
| Funding Opportunity Title: | FY09 DOD Lung Cancer Biospecimen Resource Network Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 11, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 06, 2010 |
| Current Closing Date for Applications: | Jan 06, 2010 |
| Archive Date: | Feb 05, 2010 |
| Estimated Total Program Funding: | $3,800,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The LCRP Lung Cancer Biospecimen Resource Network (LCBRN) Award is intended to provide infrastructure support for the development of a lung cancer biospecimen resource that will facilitate the collection, processing, annotation, storage, and distribution of high-quality human lung cancer biospecimens through a collaborative network across multiple institutions. The LCBRN will consist of a Coordinating Center that will also function as a biospecimen resource site and a minimum of two additional Biospecimen Resource Sites that will be jointly responsible for developing the biospecimen resource network for lung cancer research. The Coordinating Center and Biospecimen Resource Sites must submit a single application. It is expected that the Coordinating Center will provide unique resources that may not necessarily be available at each Biospecimen Resource Site and can be leveraged for the LCBRN as a group. The types of lung cancer biospecimens for this proposal may be quite diverse. A list of possible biospecimens may include but are not limited to tumor tissue, matching uninvolved lung parenchyma or airway epithelium, lung exhalant, tissue, blood, sputum, hair, toenails, and bronchoscopic brushings and biopsies. Additional requirements for the LCBRN will be the ability to collect, store, and manage data derived from these biospecimens. LCBRN applicants should possess the ability to derivatize DNA, RNA, and proteins, and also utilize both standard and state-of-the-art technologies (e.g., laser capture microdissection, tissue microarrays) to provide the necessary biospecimen processing for lung cancer research studies. The proposed LCBRN must collect, process, annotate, store, and distribute human lung cancer biospecimens that support two or more of the Areas of Emphasis listed below: Identification or development of non-invasive or minimally invasive tools to improve the detection of the initial stages of lung cancer. Identification and development of tools for screening or early detection of lung cancer. Screening may include, but is not limited to, computed tomography scans, X-rays, other imaging, biomarkers, genetics/genomics/proteomics, and assessment of risk factors. Understanding the molecular mechanisms that lead to clinically significant lung cancer. Identification of the mechanisms that lead to the development of the various types of lung cancer. Identification of innovative strategies for prevention and treatment of early lung cancer. Understanding predictive and prognostic markers to identify responders and non-responders. Understanding acquired resistance to treatment. See the Program Announcement for the full Funding Opportunity Description. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
PA HELP: 301-619-7079; cdmrp.pa@amedd.army.mil
eReceipt HELP: 301-682-5507; help@cdmrp.org Email:cdmrp.pa@amedd.army.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 49421 Full Announcement-1 -> lcrp09 lcbrn pa (9.10.09).pdf
Folder 49421 Full Announcement-1 -> biosketchjune09.pdf
Folder 49421 Full Announcement-1 -> budget form reader.pdf
Packages
| Agency Contact Information: | PA HELP: 301-619-7079; cdmrp.pa@amedd.army.mil eReceipt HELP: 301-682-5507; help@cdmrp.org Email: cdmrp.pa@amedd.army.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.420 | PKG00013968 | Sep 11, 2009 | Jan 06, 2010 | View |
Package 1
Mandatory forms
49421 RR_SF424-1.1.pdf
49421 RR_PerformanceSite-1.1.pdf
49421 RR_KeyPersonExpanded-1.1.pdf
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