This Department of Defense grant aims to fund applied research focused on enhancing treatment and function restoration for military personnel with musculoskeletal injuries from combat. The research should also benefit the general population. Proposed studies should refine concepts into potential solutions, evaluate feasibility of new products, and conduct preclinical safety studies. This grant is not for basic research or clinical trials. Two funding levels are available based on the research scope, with Level 1 for projects with preliminary data and potential for clinical translation, and Level 2 for advanced translational studies. Applications must include logical reasoning, scientific rationale, and preliminary data. Closing date for applications is Nov 19, 2015.
Opportunity ID: 277557
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-15-PRORP-ARA |
| Funding Opportunity Title: | DoD Peer Reviewed Orthopaedic Applied Research Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 4 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 30, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 19, 2015 |
| Current Closing Date for Applications: | Nov 19, 2015 |
| Archive Date: | Dec 19, 2015 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The PRORP Applied Research Award (ARA) mechanism is being offered for the first time in FY15. The PRORP ARA seeks applied research applications focused on advancing optimal treatment and restoration of function for military personnel with musculoskeletal injuries sustained during combat or combat-related activities. It is expected that any research findings would also provide benefit to the general population. To meet the intent of the award mechanism, applications must specifically address one of the FY15 PRORP ARA Focus Areas listed above. Awards may not be used to support fundamental basic research. Basic research is defined as research directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications toward process or products in mind. The FY15 PRORP ARA is focused on applied research, defined as work that refines concepts and ideas into potential solutions with a view toward evaluating technical feasibility of promising new products, pharmacologic agents, behavioral and rehabilitation interventions, diagnostic and therapeutic techniques, clinical guidance, and/or emerging approaches and technologies. Upon successful completion, these studies are expected to yield potential health products, approaches, or technologies positioned for human testing. Presentation of preliminary data is required. Inclusion of preliminary and/or published data relevant to the research question is required. In addition, investigators must demonstrate logical reasoning. In order to be competitive, the application must include a sound scientific rationale and a well formulated, testable hypothesis established through a critical review and analysis of the literature. Studies allowed under the FY15 PRORP ARA may include, but are not limited to: • Refinement of concepts and ideas into potential solutions with a view toward evaluating technical feasibility of emerging approaches, technologies, and promising new products. • Evaluation, maturation, and/or down-selection of potential product candidates (drugs, biologic constructs, or devices/systems) in vitro and/or in vivo. • Conducting preclinical safety and/or toxicity studies sufficient to support Investigational New Drug/Investigational Device Exemption (IND/IDE) applications. • Preparation activities needed to support a future clinical trial or regulatory submission. Awards may not be used to support clinical trials. A clinical trial is defined as a prospective accrual of human subjects where an intervention (e.g., device, drug, biologic, surgical procedure, rehabilitative modality, behavioral intervention, or other) is tested on a human subject for a measurable outcome with respect to exploratory information, safety, effectiveness, and/or efficacy. This outcome represents a direct effect on the human subject of that intervention or interaction. For more information on how to distinguish clinical research from clinical trials, see the Human Subject Resource Document at https://ebrap.org/eBRAP/public/Program.htm. Investigators seeking support to conduct a clinical trial should apply to the PRORP Clinical Trial Award (W81XWH-15-PRORP-CTA) mechanism, which can be accessed at http:cdmrp/army.mil/funding. Research Scope: Research proposed under the FY15 PRORP ARA may include small- to large-scale projects such as nonclinical efficacy studies, effective comparison studies, human use and/or observational studies. Two different funding levels, based on the scope of the research, are available under this Program Announcement/Funding Opportunity. It is the responsibility of the Principal Investigator (PI) to select the funding level that is most appropriate for the proposed research project. The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under each funding level: • Funding Level 1: Research that is already supported by preliminary data and has the potential to make significant advancements toward clinical translation. Demonstration of efficacy in in vivo models, as applicable. • Funding Level 2: Advanced translational studies that have the potential for near-term clinical investigation. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
CDMRP Help Desk
301-682-5507 Email:help@eBRAP.org |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 277557 Full Announcement-1 -> prorp_fy15_ara_pa_gg.pdf
Packages
| Agency Contact Information: | CDMRP Help Desk 301-682-5507 Email: help@eBRAP.org |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.420 | PKG00217654 | Jun 30, 2015 | Nov 19, 2015 | View |
Package 1
Mandatory forms
277557 RR_SF424_2_0-2.0.pdf
277557 RR_Budget_1_3-1.3.pdf
277557 RR_KeyPersonExpanded_2_0-2.0.pdf
277557 PerformanceSite_2_0-2.0.pdf
Optional forms
277557 RR_SubawardBudget30_1_3-1.3.pdf
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