This grant, through the Department of Health and Human Services, aims to support mechanistic ancillary studies in pediatric organ transplant recipients. It welcomes applications from current program directors, investigators, and laboratory leaders involved in the ‘Clinical Trials in Organ Transplantation in Children (CTOT-C)’ Program. The focus is on studying immune mechanisms related to graft dysfunction, morbidity, and mortality in pediatric transplant recipients. By leveraging existing clinical data and samples, the grant seeks to enhance understanding of pediatric transplantation, identify surrogate endpoints, and discover new therapeutic targets. Applications must be submitted by March 15, 2017.
Opportunity ID: 290353
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-16-078 |
| Funding Opportunity Title: | Limited Competition: Clinical Trials in Organ Transplantation in Children (CTOT-C): Mechanistic Ancillary Studies (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 28, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 15, 2017 |
| Current Closing Date for Applications: | Mar 15, 2017 |
| Archive Date: | Apr 15, 2017 |
| Estimated Total Program Funding: | $3,460,000 |
| Award Ceiling: | $400,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses County governments Independent school districts Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) solicits applications from currently funded Program Directors/Principal Investigators, Mechanistic Subcommittee members, core laboratory leaders and clinical site leaders in the “Clinical Trials in Organ Transplantation in Children (CTOT-C)” Program to support the conduct of studies of immune mechanisms using samples and clinical data collected from pediatric solid organ transplant recipients obtained in (a) ongoing or completed CTOT-C clinical studies, or (b) from other clinical trials in which the samples and data were collected with a demonstrably similar level of investigational rigor. Research supported under this FOA will focus on understanding graft dysfunction and/or loss and immune-mediated morbidity and mortality in pediatric transplant recipients. This FOA will leverage the samples and data gathered from CTOT-C’s unique cohort of well-characterized patients, as well as the consortium infrastructure to carry out timely hypothesis-driven mechanistic studies. Successful ancillary mechanistic investigations will enhance the value of ongoing and completed CTOT-C projects, improve the research community’s understanding of pediatric transplantation, and contribute to the identification of novel and robust surrogate endpoints for future interventional trials and/or novel therapeutic targets and biomarkers for diagnosis, treatment, and disease monitoring. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-16-078.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00229466 | Feb 15, 2017 | Mar 15, 2017 | View |
Package 1
Mandatory forms
290353 RR_SF424_2_0-2.0.pdf
290353 PHS398_CoverPageSupplement_3_0-3.0.pdf
290353 RR_OtherProjectInfo_1_3-1.3.pdf
290353 PerformanceSite_2_0-2.0.pdf
290353 RR_KeyPersonExpanded_2_0-2.0.pdf
290353 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
290353 RR_Budget_1_3-1.3.pdf
290353 RR_SubawardBudget30_1_3-1.3.pdf
290353 PHS398_ModularBudget_1_2-1.2.pdf
290353 PHS_Inclusion_Enrollment_Report-1.0.pdf
290353 PHS_AssignmentRequestForm-1.0.pdf
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