This grant aims to develop new technologies and experimental models to better understand mitochondria-cell signaling networks under environmental stress. It utilizes the R21/R33 Phased Innovation Award mechanism to enhance detection of reactive oxygen or nitrogen species, metabolic flux analysis, and identify alterations in signaling pathways. Researchers can explore mitochondrial-nuclear signaling and communication influenced by epigenetic regulation, DNA damage response, and oxidative stress. The successful completion of milestones in the R21 phase will advance projects to the R33 phase for additional pilot testing and validation. Applications are due by September 15, 2014.
Opportunity ID: 257451
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-ES-14-006 |
| Funding Opportunity Title: | Innovative Approaches for the Identification of Mitochondria-Cell Signaling Networks in Response to Environmental Stress |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 11, 2014 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 15, 2014 |
| Current Closing Date for Applications: | Sep 15, 2014 |
| Archive Date: | Oct 16, 2014 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal governments (Federally recognized) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) supports the development of technologies and experimental models to more precisely track signaling between the mitochondria and other cellular processes under environmental stress conditions, including mitochondrial-nuclear signaling with respect to epigenetic regulation, DNA damage response, or response to oxidative stress. This FOA uses the R21/R33 Phased Innovation Award mechanism to develop new technologies and experimental models to elucidate mitochondrial-cell signaling. Technologies developed in the R21 phase may include more sensitive reagents for detection of specific reactive oxygen or nitrogen species, enhanced approaches for metabolic flux analysis, and expanded in vitro or experimental models for identifying alterations in signaling pathways in response to environmental stressors. Successful completion of milestones outlined in the R21 phase will enable investigators to be considered for the R33 phase to conduct additional pilot testing and validation of these technologies using environmental stressors to probe bidirectional communication resulting in either altered cellular programming or mitochondrial function or both. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-14-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00198966 | Aug 15, 2014 | Sep 15, 2014 | View |
Package 1
Mandatory forms
257451 RR_SF424_2_0-2.0.pdf
257451 PHS398_ResearchPlan_2_0-2.0.pdf
257451 PHS398_CoverPageSupplement_2_0-2.0.pdf
257451 RR_Budget_1_3-1.3.pdf
257451 RR_KeyPersonExpanded_2_0-2.0.pdf
257451 RR_OtherProjectInfo_1_3-1.3.pdf
257451 PerformanceSite_2_0-2.0.pdf
Optional forms
257451 PlannedReport-1.0.pdf
257451 PHS398_CumulativeInclusionReport-1.0.pdf
257451 RR_SubawardBudget30_1_3-1.3.pdf
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