This department is offering the Early Detection Research Network: Clinical Validation Centers Grant (U01) to support clinical research on the validation of biomarkers for risk assessment, detection, and molecular diagnosis of early cancer. The grant aims to establish Clinical Validation Centers as clinical resource centers for collaborative biomarker validation studies within the EDRN, fostering collaboration among scientific units. The grant is part of a national effort to discover, develop, and validate biomarkers, with other key components including Biomarker Developmental Laboratories, Biomarker Reference Laboratories, and a Data Management and Coordinating Center. Applications are open until Jan 20, 2015.
Opportunity ID: 269409
General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | RFA-CA-14-015 |
| Funding Opportunity Title:: | The Early Detection Research Network: Clinical Validation Centers (U01) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Education |
| Category Explanation:: | |
| Expected Number of Awards:: | 8 |
| Assistance Listings Number(s):: | 93.394 — Cancer Detection and Diagnosis Research |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 2 |
| Posted Date:: | Nov 06, 2014 |
| Last Updated Date:: | Dec 12, 2014 |
| Original Closing Date for Applications:: | Jan 06, 2015 |
| Current Closing Date for Applications:: | Jan 20, 2015 |
| Archive Date:: | Feb 19, 2015 |
| Estimated Total Program Funding:: | $ 9,000,000 |
| Award Ceiling:: | $600,000 |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | State governments |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Clinical Validation Centers (CVCs), one of the four scientific units of the Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. The proposed CVCs will be responsible for clinical research on the validation of biomarkers. CVCs will also serve as clinical resource centers for the EDRN by participating in collaborative biomarker validation studies and collaborating with the other scientific units of the EDRN. The other three scientific components of the continuing EDRN program are: the Biomarker Developmental Laboratories (BDLs), which will be responsible for the development and characterization of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of early cancer; the Biomarker Reference Laboratories (BRLs), which will serve as Network resources for clinical and laboratory validation of biomarkers; and the Data Management and Coordinating Center (DMCC), which will support statistical and computational analyses, informatics infrastructure, study design, coordination and support of EDRN-sponsored biomarker validation studies, and the coordination of Network-wide meetings and conferences. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 2 | This RFA has had its expiration date extended per NOT-CA-15-003. | Dec 12, 2014 |
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | |
| Competition ID: | FORMS-C |
| Competition Title: | FORMS-C |
| Opportunity Package ID: | PKG00209684 |
| Opening Date: | Dec 20, 2014 |
| Closing Date: | Jan 20, 2015 |
| Agency Contact Information:: | eRA Commons Help Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0] |
| optional_forms |
R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3] |
Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00209684 | Dec 20, 2014 | Jan 20, 2015 | View | eRA Commons Help Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ | Organization Applicants |