This grant, offered by the Department of Health, aims to support milestone-driven projects crucial for advancing therapeutic discovery. Specifically, it focuses on developing and leveraging novel predictive models, assays, tools, and platforms. These innovations will be based on understanding the penetration and efflux mechanisms of small molecules, critical for effective drug development. The primary purpose is to facilitate the discovery of new therapies targeting select antibiotic-resistant Gram-negative bacterial pathogens. These include highly problematic strains such as carbapenem-resistant Acinetobacter, carbapenem-resistant Enterobacteriaceae (CRE), and multidrug-resistant Pseudomonas aeruginosa, addressing a significant public health challenge. This initiative seeks to foster partnerships to accelerate the development of much-needed tools in the fight against these difficult-to-treat infections.
Opportunity ID: 353311
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-24-021 |
| Funding Opportunity Title: | Partnerships for the Development of Tools to Advance Therapeutic Discovery for Select Antibiotic-Resistant Gram-Negative Bacteria (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 01, 2024 |
| Last Updated Date: | Apr 01, 2024 |
| Original Closing Date for Applications: | Aug 20, 2024 |
| Current Closing Date for Applications: | Aug 20, 2024 |
| Archive Date: | Sep 25, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities Special district governments For profit organizations other than small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to support milestone-driven projects focused on developing and utilizing novel predictive models, assays, tools, and/or platforms based on penetration and efflux of small molecules to facilitate therapeutic discovery for select Gram-negative bacterial pathogens: carbapenem-resistant Acinetobacter, carbapenem-resistant Enterobacteriaceae (CRE), and multidrug-resistant Pseudomonas aeruginosa. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-021.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 353311 Full Announcement-RFA-AI-24-021 -> RFA-AI-24-021-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00285667 | Jul 20, 2024 | Aug 20, 2024 | View |
Package 1
Mandatory forms
353311 RR_SF424_5_0-5.0.pdf
353311 PHS398_CoverPageSupplement_5_0-5.0.pdf
353311 RR_OtherProjectInfo_1_4-1.4.pdf
353311 PerformanceSite_4_0-4.0.pdf
353311 RR_KeyPersonExpanded_4_0-4.0.pdf
353311 PHS398_ResearchPlan_5_0-5.0.pdf
353311 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
353311 RR_Budget_3_0-3.0.pdf
353311 RR_SubawardBudget30_3_0-3.0.pdf
353311 PHS398_ModularBudget_1_2-1.2.pdf
353311 PHS_AssignmentRequestForm_3_0-3.0.pdf
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