DOD’s Peer Reviewed Alzheimer’s Grant for Transformative AD/ADRD Research

The FY23 PRARP TRA is intended to support studies that will make transformative and advanced contributions to reduce risk of or prevent the development of AD/ADRD. Risk reduction considering TBI and/or military service is of particular interest to the program. The work should significantly accelerate efforts in AD/ADRD research and demonstrate significant positive impact toward improving patient care and/or quality of life.

Key elements of this award mechanism include:

• Research should be robust: The FY23 PRARP TRA mechanism is geared toward supporting robust, well designed research projects that provide significant, near-term impact on the AD/ADRD field, persons living with dementia, and their families, care-partners/caregivers, and communities. To ensure near-term applicability, inclusion of collaborative community partner approaches is strongly encouraged for all projects and is required for all projects involving clinical research.

• Non-incremental advancement: Research projects should leverage existing knowledge to accelerate ideas, strengthen evidence, and move the field forward toward nearer-term impact. Projects proposing incremental advances that do not significantly propel the field are not appropriate for this mechanism.

• Feedback to the community: Results and outcomes of the research supported by this mechanism must be relayed back to the community to allow for continued knowledge building.

Inclusion of preliminary data is required. Use of animal models must be fully justified for relevance to human health. Clinical research applications are required to include a community collaboration research element.

The FY23 PRARP TRA is intended to support studies that will make transformative and advanced contributions to reduce risk of or prevent the development of AD/ADRD. Risk reduction considering TBI and/or military service is of particular interest to the program. The work should significantly accelerate efforts in AD/ADRD research and demonstrate significant positive impact toward improving patient care and/or quality of life.

Key elements of this award mechanism include:

• Research should be robust: The FY23 PRARP TRA mechanism is geared toward supporting robust, well designed research projects that provide significant, near-term impact on the AD/ADRD field, persons living with dementia, and their families, care-partners/caregivers, and communities. To ensure near-term applicability, inclusion of collaborative community partner approaches is strongly encouraged for all projects and is required for all projects involving clinical research.

• Non-incremental advancement: Research projects should leverage existing knowledge to accelerate ideas, strengthen evidence, and move the field forward toward nearer-term impact. Projects proposing incremental advances that do not significantly propel the field are not appropriate for this mechanism.

• Feedback to the community: Results and outcomes of the research supported by this mechanism must be relayed back to the community to allow for continued knowledge building.

Inclusion of preliminary data is required. Use of animal models must be fully justified for relevance to human health. Clinical research applications are required to include a community collaboration research element.