DOE BER Grant for Integrated Radiochemistry Research Excellence and Training

1995.

Integrated involvement of graduate-student and postdoctoral trainees in the

fundamental research that seeks improvements in radiolabeling and
radiotracer
development chemistry in the following areas of interest to BER: a)
Development
of new chemical reactions for high specific activity probe synthesis, b)
Models
to study reactivity at the tracer mass scale, c) Nanoparticle platforms
that
can incorporate one or more imaging agents and d) Automation technology for

radiotracer synthesis, and 2) Enhancement of training opportunities in
radiochemistry to ensure the future availability of human resources for
important radiochemistry applications. Such applications include the
development of fundamental radiotracer methodologies for both BER mission-
relevant biological research needs in the context of energy and
environment,
and for use in technological advances in nuclear medicine research.
Applicant
Projects must have access to existing advanced facilities and an
interdisciplinary collaborative team of nuclear chemists, radiochemists,
synthetic chemists and biochemists able to support a robust research
training
environment. Institutional settings should offer broad ranging research
collaborations with other federally-funded and/or private sector-funded
investigators to allow: i) opportunities to link radionuclide production
research to incorporation of radioisotopes in a wide range of organic
molecules
for radiolabeled probe development, and ii) the use of these new probes and

methodologies for quantitative in vivo measurement of site-specific (in
situ)
chemical reactions, their metabolic perturbations and the ensuing
biological
processes. For details, refer to supplementary information
below.