The Federal Health Research Department is offering this grant to significantly advance the discovery of pharmacotherapeutics for Substance Use Disorders (SUD). This grant is for the purpose of fostering the development of innovative artificial intelligence (AI) tools and sophisticated experimental assays. The core objective is to identify novel pharmacotherapeutic candidates exhibiting both lower toxicity and higher efficacy for SUD treatment. Specific areas of interest include the creation of advanced AI tools to identify potential target combinations, design new molecules, and conduct virtual preclinical studies predicting efficacy and toxicity, alongside modeling in vitro and in vivo polypharmacology. Additionally, the grant supports the development of assays to comprehensively assess compound effects on multiple biological targets or functions. This initiative aims to accelerate the availability of safer, more effective SUD interventions.
Opportunity ID: 352047
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-25-053 |
| Funding Opportunity Title: | Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 29, 2024 |
| Last Updated Date: | Jan 29, 2024 |
| Original Closing Date for Applications: | Jul 25, 2024 |
| Current Closing Date for Applications: | Jul 25, 2024 |
| Archive Date: | Aug 30, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $400,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-053.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 352047 Full Announcement-RFA-DA-25-053 -> RFA-DA-25-053-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00284613 | Jun 25, 2024 | Jul 25, 2024 | View |
Package 1
Mandatory forms
352047 RR_SF424_5_0-5.0.pdf
352047 PHS398_CoverPageSupplement_5_0-5.0.pdf
352047 RR_OtherProjectInfo_1_4-1.4.pdf
352047 PerformanceSite_4_0-4.0.pdf
352047 RR_KeyPersonExpanded_4_0-4.0.pdf
352047 RR_Budget_3_0-3.0.pdf
352047 RR_SubawardBudget30_3_0-3.0.pdf
352047 PHS398_ResearchPlan_5_0-5.0.pdf
352047 SBIR_STTR_Information_3_0-3.0.pdf
352047 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
352047 PHS_AssignmentRequestForm_3_0-3.0.pdf
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