This grant is offered to support innovative mechanistic research focused on accelerating precision probiotic interventions. Its primary purpose is to characterize person-specific biological features, such as the microbiome, immune system, genetics, diet, and lifestyle, that influence responses to probiotics. By understanding these individual variations, the initiative aims to identify subgroups of responders and enhance clinical outcomes. The ultimate goal is to overcome barriers caused by human heterogeneity, which leads to inconsistent probiotic effects. Applications should propose rigorously designed studies, using relevant animal models or human subjects, to test the causality or predictability of identified host biological patterns related to probiotic usage. This funding will advance our understanding and development of more effective, personalized probiotic therapies.
Opportunity ID: 356927
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-210 |
| Funding Opportunity Title: | Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 31, 2024 |
| Last Updated Date: | Oct 31, 2024 |
| Original Closing Date for Applications: | Jun 02, 2027 |
| Current Closing Date for Applications: | Jun 02, 2027 |
| Archive Date: | Jul 08, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Small businesses For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments Special district governments Public housing authorities/Indian housing authorities Private institutions of higher education County governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-210.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356927 Full Announcement-PAR-25-210 -> PAR-25-210-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288344 | May 02, 2025 | Jun 02, 2027 | View |
Package 1
Mandatory forms
356927 RR_SF424_5_0-5.0.pdf
356927 PHS398_CoverPageSupplement_5_0-5.0.pdf
356927 RR_OtherProjectInfo_1_4-1.4.pdf
356927 PerformanceSite_4_0-4.0.pdf
356927 RR_KeyPersonExpanded_4_0-4.0.pdf
356927 RR_Budget_3_0-3.0.pdf
356927 PHS398_ResearchPlan_5_0-5.0.pdf
356927 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356927 RR_SubawardBudget30_3_0-3.0.pdf
356927 PHS_AssignmentRequestForm_4_0-4.0.pdf
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