Health and Human Services Committee: Innovative Approaches in Chronic Illness Research Grants

The Health and Human Services Committee is offering grants for innovative research methods aimed at prevention and management of symptoms in chronic illness. This grant opportunity encourages the update of randomized control trial (RCT) designs using novel research methods to improve outcomes in symptom management. Applicants are encouraged to explore novel clinical research designs such as Sequential Multiple Assignment Randomization Trials (SMART) and Multiphase Optimization Strategies (MOST) for more effective interventions. The focus is on addressing treatment responses variability, subject retention, and adherence to treatment regimens. Proposal deadline is May 07, 2016.

Opportunity ID: 228549

Apply

General Information

Document Type::	Grants Notice
Funding Opportunity Number::	PA-13-166
Funding Opportunity Title::	Innovative Research Methods: Prevention and Management of Symptoms in Chronic Illness (R15)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Education
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.361 — Nursing Research
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 1
Posted Date::	Mar 29, 2013
Last Updated Date::
Original Closing Date for Applications::	May 07, 2016
Current Closing Date for Applications::	May 07, 2016
Archive Date::	Jun 07, 2016
Estimated Total Program Funding::
Award Ceiling::	$300,000
Award Floor::	$

Eligibility

Eligible Applicants::

Private institutions of higher education

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	This funding opportunity seeks to update the randomized control trial (RCT) design using novel research methods that are practical, innovative, and hold promise for producing more effective outcomes. Novel clinical research designs, applied to symptom management trials, may identify those treatment strategies that best alter the course of symptom burden in chronic illness by addressing the issues of varied treatment responses across patients, subject retention, and adherence to treatment regimens. For example, sequential multiple assignment randomization trials (SMART) design have been used successfully to develop dynamic treatment regimens for alcohol, depression and HIV infection but are not widely used in symptom management trials. The approach is pragmatic in that it mimics clinical practice by allowing a re-evaluation of treatment options based on an individuals progress towards treatment goals. The levels or inclusion of intervention components are tailored in response to individual characteristics or progress toward a treatment goal. Subjects may be randomly assigned several times to varying amounts and types of intervention components based on predetermined decision rules. This sequential decision making process allows for the initial intervention to be adapted and provides subjects with options for achieving a favorable outcome. A Multiphase optimization strategy (MOST) could also prove useful when applied to symptom management trials.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:
Competition ID:	ADOBE-FORMS-B2
Competition Title:	Adobe-Forms-B2
Opportunity Package ID:	PKG00171755
Opening Date:	May 25, 2013
Closing Date:	Sep 24, 2013
Agency Contact Information::	eRA Commons Help Desk
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2]