This Health Research Department grant supports clinical sites for the HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network. The network will conduct pragmatic trials to optimize cervical cancer screening, management, and precancer treatment for women living with HIV. Areas of focus include improving screening uptake, managing screen-positives, and facilitating precancer treatment access. The generated evidence will refine clinical guidelines and inform public health policy, enhancing prevention programs. This funding establishes 6-8 clinical sites, providing infrastructure for prevention trials and offering expert clinical insights to the CASCADE network.
Opportunity ID: 343912
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-22-051 |
| Funding Opportunity Title: | Clinical Sites for HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network (UG1 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 03, 2022 |
| Last Updated Date: | Oct 03, 2022 |
| Original Closing Date for Applications: | Dec 28, 2022 |
| Current Closing Date for Applications: | Dec 28, 2022 |
| Archive Date: | Feb 02, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Special district governments Small businesses State governments City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network seeks to evaluate innovative approaches for overcoming barriers and reducing failures in the cervical cancer screening and treatment cascade for women living with HIV. The proposed multicenter network will conduct pragmatic clinical trials to evaluate the effectiveness of clinically proven interventions in intended-use settings with a goal to optimize the cervical cancer screening, management, and precancer treatment cascade for women living with HIV. These trials will focus on the health care continuum for secondary cervical cancer prevention, i.e., increasing screening uptake, improving management of screen positives, facilitating precancer treatment access, and optimizing precancer treatments. Data from these trials will be used to provide the necessary evidence to refine clinical practice guidelines and inform public health policy with a goal to generate crucial actionable evidence for improving cervical cancer prevention implementation programs. Six-to-eight UG1 cooperative agreement mechanism-funded Clinical Sites, led by clinical investigators and/or clinicians, will provide a pluripotent clinical infrastructure to conduct/implement multiple prevention clinical trials through the CASCADE network and interface with network grantees during concept and protocol development to provide insights and input on clinical significance and study feasibility. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-22-051.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 343912 Full Announcement-RFA-CA-22-051 -> RFA-CA-22-051-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00277132 | Nov 28, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277616 | Nov 28, 2022 | Dec 28, 2022 | View |
Package 1
Mandatory forms
343912 RR_SF424_5_0-5.0.pdf
343912 PHS398_CoverPageSupplement_5_0-5.0.pdf
343912 RR_OtherProjectInfo_1_4-1.4.pdf
343912 PerformanceSite_4_0-4.0.pdf
343912 RR_KeyPersonExpanded_4_0-4.0.pdf
343912 RR_Budget_3_0-3.0.pdf
343912 PHS398_ResearchPlan_4_0-4.0.pdf
343912 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343912 RR_SubawardBudget30_3_0-3.0.pdf
343912 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343912 RR_SF424_5_0-5.0.pdf
343912 PHS398_CoverPageSupplement_5_0-5.0.pdf
343912 RR_OtherProjectInfo_1_4-1.4.pdf
343912 PerformanceSite_4_0-4.0.pdf
343912 RR_KeyPersonExpanded_4_0-4.0.pdf
343912 RR_Budget_3_0-3.0.pdf
343912 PHS398_ResearchPlan_5_0-5.0.pdf
343912 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343912 RR_SubawardBudget30_3_0-3.0.pdf
343912 PHS_AssignmentRequestForm_3_0-3.0.pdf
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