The Health Research Department is offering this grant to support critical investigations into HIV-1 mechanisms, particularly focusing on the virus’s Envelope (Env) protein. This funding opportunity aims to explore HIV-1 Env cell surface expression and clarify the structural basis by which biologic agents induce cell killing. A key objective of this grant is to foster the development of novel approaches designed to enhance the recognition and subsequent elimination of HIV-1 infected cells expressing the Env protein. Ultimately, this grant is for the purpose of generating foundational knowledge and crucial insights that will directly inform and accelerate the creation of advanced immunotherapies and targeted vaccine strategies, vital for the prevention and potential cure of HIV-1 infection globally.
Opportunity ID: 357488
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-300 |
| Funding Opportunity Title: | Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 02, 2024 |
| Last Updated Date: | Dec 02, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Independent school districts Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses State governments Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support the investigation of HIV-1 Envelope (Env) cell surface expression, the structural mechanism of biologic-mediated cell killing, and the development of novel approaches to enhance the recognition and elimination of Env-expressing, HIV-1 infected cells. These studies are expected to inform the development of immunotherapies and targeted vaccines for HIV-1 prevention and cure. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-300.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357488 Full Announcement-PAR-25-300 -> PAR-25-300-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289345 | Apr 07, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357488 RR_SF424_5_0-5.0.pdf
357488 PHS398_CoverPageSupplement_5_0-5.0.pdf
357488 RR_OtherProjectInfo_1_4-1.4.pdf
357488 PerformanceSite_4_0-4.0.pdf
357488 RR_KeyPersonExpanded_4_0-4.0.pdf
357488 PHS398_ResearchPlan_5_0-5.0.pdf
357488 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357488 RR_Budget_3_0-3.0.pdf
357488 RR_SubawardBudget30_3_0-3.0.pdf
357488 PHS398_ModularBudget_1_2-1.2.pdf
357488 PHS_AssignmentRequestForm_4_0-4.0.pdf
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