This grant is for expanding knowledge on the natural history of disorders identifiable through statewide newborn screening programs. A comprehensive understanding of these conditions is crucial for developing effective interventions and targeted treatments for affected infants. Research funded by this opportunity will characterize symptom development, explore genotype-phenotype correlations, and identify modifying factors. The goal is to improve diagnostic accuracy, facilitate clinical trials by providing essential natural history data, and ultimately enhance the prevention, management, and treatment of these conditions. The findings will also support physicians and families with predictive information and help establish longitudinal data collection systems.
Opportunity ID: 357010
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-227 |
| Funding Opportunity Title: | Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities County governments Public and State controlled institutions of higher education Private institutions of higher education For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) encourages applications that will expand knowledge of the natural history of disorders that currently are, or may become, part of statewide newborn screening programs. A comprehensive understanding of the natural history of a condition is necessary to facilitate appropriate interventions for infants identified by newborn screening. Characterization of the sequence and timing of symptom development provides information crucial for developing targeted, age-appropriate treatments and for establishing a baseline against which to assess novel interventions. In addition, for some conditions, establishment of genotype-phenotype correlations may facilitate prediction of the clinical course; for others, identification of modifying genetic, epigenetic, or environmental factors may enhance understanding of clinical outcomes. Comprehensive data on the natural history of a condition will facilitate the fields ability to: 1) identify the underlying biological mechanisms; 2) understand the genetic and clinical heterogeneity and phenotypic expression of the condition; 3) improve diagnostic accuracy; 4) facilitate clinical trials by providing comprehensive natural history data; 5) prevent, manage, and treat symptoms and complications of the condition; 6) furnish physicians and families with needed support and predictive information about the condition; and 7) establish data collection systems or patient registries to collect longitudinal data (e.g., child/family outcomes following newborn screening). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-227.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357010 Full Announcement-PAR-25-227 -> PAR-25-227-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288549 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357010 RR_SF424_5_0-5.0.pdf
357010 PHS398_CoverPageSupplement_5_0-5.0.pdf
357010 RR_OtherProjectInfo_1_4-1.4.pdf
357010 PerformanceSite_4_0-4.0.pdf
357010 RR_KeyPersonExpanded_4_0-4.0.pdf
357010 PHS398_ResearchPlan_5_0-5.0.pdf
357010 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357010 RR_Budget_3_0-3.0.pdf
357010 RR_SubawardBudget30_3_0-3.0.pdf
357010 PHS398_ModularBudget_1_2-1.2.pdf
357010 PHS_AssignmentRequestForm_4_0-4.0.pdf
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