This health research funding opportunity supports the continued follow-up of the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort, an observational study launched after the Diabetes Control and Complications Trial (DCCT). The DCCT demonstrated intensive therapy significantly reduced diabetes complications. This grant is for the EDIC Research Center to evaluate the long-term effects of DCCT intensive therapy and characterize Type 1 diabetes complications. The primary purpose is to continue studying the development and longer-term course of Type 1 diabetes, including severe microvascular disease, cardiovascular disease, liver disease, sleep disorders, and mortality. The Center will manage and support clinical activities for these crucial research objectives.
Opportunity ID: 335337
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-21-503 |
| Funding Opportunity Title: | Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 17, 2021 |
| Last Updated Date: | Aug 17, 2021 |
| Original Closing Date for Applications: | Nov 30, 2021 |
| Current Closing Date for Applications: | Nov 30, 2021 |
| Archive Date: | Jan 05, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $6,300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. see funding announcement for eligibility details |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to continue to follow the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort through a collaborative cooperative agreement. EDIC is an observational study that was launched at the completion of the Diabetes Control and Complications Trial (DCCT) trial. The DCCT showed that intensive therapy significantly reduced the risk of diabetes complications compared to conventional therapy. At DCCT completion, all cohort members were taught intensive diabetes therapy. In 1994, EDIC was launched to: (1) evaluate the long-term effects of DCCT intensive therapy, (2) describe the long-term effects of glycemia and other risk factors on diabetes complications, and (3) characterize type1 diabetes complicationsby supporting collaborative research to utilize the EDIC cohort as well as its data set and biologic/genetic samples. To date, EDIC has: (1) demonstrated a continued benefit of intensive therapy on the development and progression of diabetes complications, and (2) characterized the development and progression of diabetes complications. The primary purpose of this FOA is to support the EDIC Research Center to continue follow-up of the EDIC cohort to study the development of complications and the longer term course of type 1 diabetes in a well characterized type 1 diabetes population, including but not limited to severe microvascular disease (blindness, kidney failure, amputation),cardiovascular disease, liver disease, sleep disorders and mortality. The EDIC Research Center will manage and support EDIC Clinical Centers, which are responsible for the conduct of all EDIC core activities as described in the protocol and Manual of Operations and as required by the local and central Institutional Review Boards. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-21-503.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268602 | Oct 30, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270437 | Nov 18, 2021 | Nov 30, 2021 | View |
Package 1
Mandatory forms
335337 RR_SF424_2_0-2.0.pdf
335337 PHS398_CoverPageSupplement_5_0-5.0.pdf
335337 RR_OtherProjectInfo_1_4-1.4.pdf
335337 PerformanceSite_2_0-2.0.pdf
335337 RR_KeyPersonExpanded_2_0-2.0.pdf
335337 PHS398_ResearchPlan_4_0-4.0.pdf
335337 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335337 RR_Budget_1_4-1.4.pdf
335337 RR_SubawardBudget30_1_4-1.4.pdf
335337 PHS398_ModularBudget_1_2-1.2.pdf
335337 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
335337 RR_SF424_5_0-5.0.pdf
335337 PHS398_CoverPageSupplement_5_0-5.0.pdf
335337 RR_OtherProjectInfo_1_4-1.4.pdf
335337 PerformanceSite_4_0-4.0.pdf
335337 RR_KeyPersonExpanded_4_0-4.0.pdf
335337 PHS398_ResearchPlan_4_0-4.0.pdf
335337 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
335337 RR_Budget_3_0-3.0.pdf
335337 RR_SubawardBudget30_3_0-3.0.pdf
335337 PHS398_ModularBudget_1_2-1.2.pdf
335337 PHS_AssignmentRequestForm_3_0-3.0.pdf
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