The Immune Tolerance Network is offering a grant to develop tolerogenic approaches for treating asthma and allergic diseases, autoimmune diseases, and immune-mediated consequences of allotransplantation. The grant supports the design and conduct of clinical trials, mechanistic studies, development of tolerance assays, establishment of biospecimen repositories, and provision of bioinformatics resources. Additionally, nonclinical studies may be supported to evaluate tolerance induction approaches. Applications for this grant must be submitted by March 3, 2020.
Opportunity ID: 322890
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-19-068 |
| Funding Opportunity Title: | Immune Tolerance Network (UM1 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 06, 2019 |
| Last Updated Date: | Dec 06, 2019 |
| Original Closing Date for Applications: | Mar 03, 2020 |
| Current Closing Date for Applications: | Mar 03, 2020 |
| Archive Date: | Apr 08, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Small businesses County governments Independent school districts Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Private institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Immune Tolerance Network. The major goal of this Network is to develop tolerogenic approaches for the treatment and prevention of disease in three clinical areas: asthma and allergic diseases; autoimmune diseases; and immune-mediated consequences of allotransplantation. The scope of research to be carried out includes: 1) the design and conduct of clinical trials at all phases to evaluate the safety and efficacy of investigational products and approaches for the induction and maintenance of immune tolerance in humans; 2) the design and conduct of mechanistic studies and the development of tolerance assays as integral components of the clinical trials undertaken, including establishing and directing a consortium of laboratories; and one or more biospecimen repositories, and 3) the provision of bioinformatics, data collection, validation and analysis resources. In addition, on a limited basis, the Network may support focused product development and nonclinical studies (e.g., toxicology, pharmacology, pharmacokinetics, etc.) essential for the subsequent evaluation of promising tolerance induction approaches in humans. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-19-068.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00257011 | Feb 03, 2020 | May 24, 2020 | View |
Package 1
Mandatory forms
322890 RR_SF424_2_0-2.0.pdf
322890 PHS398_CoverPageSupplement_4_0-4.0.pdf
322890 RR_OtherProjectInfo_1_4-1.4.pdf
322890 PerformanceSite_2_0-2.0.pdf
322890 RR_KeyPersonExpanded_2_0-2.0.pdf
322890 RR_Budget10_1_4-1.4.pdf
322890 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
322890 RR_SubawardBudget10_30_1_4-1.4.pdf
322890 PHS_AssignmentRequestForm_2_0-2.0.pdf
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