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Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)

Opportunity ID: 360679

General Information

Funding Opportunity Number RFA-DK-27-125
Funding Opportunity Title Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
Agency National Institutes of Health
Document Type synopsis
Version 1
Opportunity Category Discretionary
Opportunity Category Explanation Not specified
Funding Instrument Type Cooperative Agreement
Category of Funding Activity Health
Category Explanation Not specified
Expected Number of Awards 3
Cost Sharing or Matching Requirement No
Posted Date Aug 31, 2026 12:00:00 AM EDT
Last Updated Date Aug 31, 2026 10:13:52 AM EDT
Original Closing Date Nov 06, 2026 12:00:00 AM EST
Original Closing Date Notes Not specified
Current Closing Date Nov 06, 2026 12:00:00 AM EST
Current Closing Date Notes Not specified
Estimated Synopsis Date Not specified
Estimated Application Due Date Not specified
Estimated Award Date Not specified
Estimated Project Start Date Not specified
Archive Date Jan 05, 2027 12:00:00 AM EST
Estimated Total Program Funding 1,850,000
Award Ceiling none
Award Floor none

Assistance Listings

  • 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research

Eligibility

Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.As this NOFO is a Limited Competition, only the current recipients under RFA-DK-20-011 are eligible to apply under this announcement.As this NOFO is a limited competition opportunity, only the institutions that are the principal employer of the Program Director/Principal Investigator of the original COPE-AKI Participating Clinical Centers and the COPE-AKI Scientific Data Research Center are eligible to apply in response to this NOFO.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Description

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding. This NOFO requests limited competition applications for a 3-year extension of the COPE-AKI clinical trial consortium, which includes three clinical centers (CCs) and one scientific and data research center (SDRC), to fully meet the enrollment targets, complete participant follow-up, and provide resources for data analysis and dissemination of study findings. There is currently no standard of care for patients after hospitalization with acute kidney injury (AKI). Successful completion of the COPE-AKI study will provide key insights that are expected to directly inform improved clinical management strategies and the development of standard of care for Stage 2 and 3 AKI survivors.

Additional Information

Contact National Institutes of Health
Contact Information Division of Kidney, Urologic, and Hematologic Diseases
NIDDK_KUH@nih.gov
Email NIDDK_KUH@nih.gov
Email Description NIDDK_KUH@nih.gov
Phone 301-402-2541

Additional information

Version History

Version history

Opp hist id / Opportunity id 360679
Opp hist id / Revision 1
Opportunity id 360679
Revision 1
Opportunity number RFA-DK-27-125
Opportunity title Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
Owning agency code HHS-NIH11
Opportunity category / Category D
Opportunity category / Description Discretionary
Forecast / Opp hist id / Opportunity id 360679
Forecast / Opp hist id / Revision 1
Forecast / Opportunity id 360679
Forecast / Revision 1
Forecast / Version 1
Forecast / Posting date Sep 30, 2025 12:00:00 AM EDT
Forecast / Forecast desc This NOFO requests limited competition applications for a 3-year extension of the COPE-AKI clinical trial consortium, which includes three clinical centers (CCs) and one scientific and data research center (SDRC), are requested to fully meet the enrollment targets, complete participant follow-up, and provide resources for data analysis and dissemination of study findings. There is currently no standard of care for patients after hospitalization with acute kidney injury (AKI). Successful completion of the COPE-AKI study will provide key insights that are expected to directly inform improved clinical management strategies and the development of standard of care for Stage 2 and 3 AKI survivors.
 
This is a forecast for a limited competition Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.
Forecast / Cost sharing No
Forecast / Number of awards 3
Forecast / Estimated funding 2500000
Forecast / Agency contact name Ivonne Schulman
Forecast / Agency contact phone 301-435-3350
Forecast / Agency contact email ivonne.schulman@nih.gov
Forecast / Agency contact email desc ivonne.schulman@nih.gov
Forecast / Agency code HHS-NIH11
Forecast / Applicant eligibility desc Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Forecast / Est synopsis posting date Apr 01, 2026 12:00:00 AM EDT
Forecast / Est application response date Jul 01, 2026 12:00:00 AM EDT
Forecast / Est award date Jan 01, 2027 12:00:00 AM EST
Forecast / Est project start date Feb 01, 2027 12:00:00 AM EST
Forecast / Fiscal year 2027
Forecast / Create time stamp Sep 30, 2025 09:20:09 AM EDT
Forecast / Action type U
Forecast / Action date Aug 31, 2026 10:13:52 AM EDT
Forecast / Created date Sep 30, 2025 09:20:09 AM EDT
Forecast / Last updated date Sep 30, 2025 09:20:09 AM EDT
Forecast / Agency details / Code NIH
Forecast / Agency details / Seed HHS-NIH11
Forecast / Agency details / Agency name National Institutes of Health
Forecast / Agency details / Agency code HHS-NIH11
Forecast / Agency details / Top agency code HHS
Forecast / Estimated funding formatted 2,500,000
Forecast / Applicant types 1 / Id 22
Forecast / Applicant types 1 / Description For profit organizations other than small businesses
Forecast / Applicant types 2 / Id 25
Forecast / Applicant types 2 / Description Others (see text field entitled "Additional Information on Eligibility" for clarification)
Forecast / Applicant types 3 / Id 01
Forecast / Applicant types 3 / Description County governments
Forecast / Applicant types 4 / Id 12
Forecast / Applicant types 4 / Description Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Forecast / Applicant types 5 / Id 00
Forecast / Applicant types 5 / Description State governments
Forecast / Applicant types 6 / Id 07
Forecast / Applicant types 6 / Description Native American tribal governments (Federally recognized)
Forecast / Applicant types 7 / Id 20
Forecast / Applicant types 7 / Description Private institutions of higher education
Forecast / Applicant types 8 / Id 11
Forecast / Applicant types 8 / Description Native American tribal organizations (other than Federally recognized tribal governments)
Forecast / Applicant types 9 / Id 08
Forecast / Applicant types 9 / Description Public housing authorities/Indian housing authorities
Forecast / Applicant types 10 / Id 13
Forecast / Applicant types 10 / Description Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Forecast / Applicant types 11 / Id 23
Forecast / Applicant types 11 / Description Small businesses
Forecast / Applicant types 12 / Id 02
Forecast / Applicant types 12 / Description City or township governments
Forecast / Applicant types 13 / Id 06
Forecast / Applicant types 13 / Description Public and State controlled institutions of higher education
Forecast / Applicant types 14 / Id 05
Forecast / Applicant types 14 / Description Independent school districts
Forecast / Applicant types 15 / Id 04
Forecast / Applicant types 15 / Description Special district governments
Forecast / Funding instruments 1 / Id CA
Forecast / Funding instruments 1 / Description Cooperative Agreement
Forecast / Funding activity categories 1 / Id HL
Forecast / Funding activity categories 1 / Description Health
Forecast / Posting date str 2025-09-30-00-00-00
Forecast / Est synopsis posting date str 2026-04-01-00-00-00
Forecast / Est application response date str 2026-07-01-00-00-00
Forecast / Est award date str 2027-01-01-00-00-00
Forecast / Est project start date str 2027-02-01-00-00-00
Forecast / Create time stamp str 2025-09-30-09-20-09
Cfdas 1 / Id 431239
Cfdas 1 / Opportunity id 360679
Cfdas 1 / Revision 0
Cfdas 1 / Cfda number 93.847
Cfdas 1 / Program title Diabetes, Digestive, and Kidney Diseases Extramural Research
Synopsis modified fields Not specified
Forecast modified fields Not specified

Forecast changes

revision

version

archiveDate

modComments

createTimeStamp

Id 360679
Revision 2
Opportunity number RFA-DK-27-125
Opportunity title Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
Owning agency code HHS-NIH11
Opportunity category / Category D
Opportunity category / Description Discretionary
Synopsis / Opportunity id 360679
Synopsis / Version 1
Synopsis / Agency code HHS-NIH11
Synopsis / Agency name National Institutes of Health
Synopsis / Agency phone 301-402-2541
Synopsis / Agency address desc NIDDK_KUH@nih.gov
Synopsis / Agency details / Code NIH
Synopsis / Agency details / Seed HHS-NIH11
Synopsis / Agency details / Agency name National Institutes of Health
Synopsis / Agency details / Agency code HHS-NIH11
Synopsis / Agency details / Top agency code HHS
Synopsis / Top agency details / Code HHS
Synopsis / Top agency details / Seed HHS
Synopsis / Top agency details / Agency name Department of Health and Human Services
Synopsis / Top agency details / Agency code HHS
Synopsis / Top agency details / Top agency code HHS
Synopsis / Agency contact phone 301-402-2541
Synopsis / Agency contact name National Institutes of Health
Synopsis / Agency contact desc Division of Kidney, Urologic, and Hematologic Diseases
NIDDK_KUH@nih.gov
Synopsis / Agency contact email NIDDK_KUH@nih.gov
Synopsis / Agency contact email desc NIDDK_KUH@nih.gov
Synopsis / Synopsis desc This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding. This NOFO requests limited competition applications for a 3-year extension of the COPE-AKI clinical trial consortium, which includes three clinical centers (CCs) and one scientific and data research center (SDRC), to fully meet the enrollment targets, complete participant follow-up, and provide resources for data analysis and dissemination of study findings. There is currently no standard of care for patients after hospitalization with acute kidney injury (AKI). Successful completion of the COPE-AKI study will provide key insights that are expected to directly inform improved clinical management strategies and the development of standard of care for Stage 2 and 3 AKI survivors.
Synopsis / Response date Nov 06, 2026 12:00:00 AM EST
Synopsis / Posting date Aug 31, 2026 12:00:00 AM EDT
Synopsis / Archive date Jan 05, 2027 12:00:00 AM EST
Synopsis / Cost sharing No
Synopsis / Number of awards 3
Synopsis / Estimated funding 1850000
Synopsis / Estimated funding formatted 1,850,000
Synopsis / Award ceiling none
Synopsis / Award floor none
Synopsis / Applicant eligibility desc Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.As this NOFO is a Limited Competition, only the current recipients under RFA-DK-20-011 are eligible to apply under this announcement.As this NOFO is a limited competition opportunity, only the institutions that are the principal employer of the Program Director/Principal Investigator of the original COPE-AKI Participating Clinical Centers and the COPE-AKI Scientific Data Research Center are eligible to apply in response to this NOFO.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Synopsis / Create time stamp Aug 31, 2026 10:14:02 AM EDT
Synopsis / Created date Aug 31, 2026 10:13:52 AM EDT
Synopsis / Last updated date Aug 31, 2026 10:13:52 AM EDT
Synopsis / Applicant types 1 / Id 25
Synopsis / Applicant types 1 / Description Others (see text field entitled "Additional Information on Eligibility" for clarification)
Synopsis / Funding instruments 1 / Id CA
Synopsis / Funding instruments 1 / Description Cooperative Agreement
Synopsis / Funding activity categories 1 / Id HL
Synopsis / Funding activity categories 1 / Description Health
Synopsis / Response date str 2026-11-06-00-00-00
Synopsis / Posting date str 2026-08-31-00-00-00
Synopsis / Archive date str 2027-01-05-00-00-00
Synopsis / Create time stamp str 2026-08-31-10-14-02
Agency details / Code NIH
Agency details / Seed HHS-NIH11
Agency details / Agency name National Institutes of Health
Agency details / Agency code HHS-NIH11
Agency details / Top agency code HHS
Top agency details / Code HHS
Top agency details / Seed HHS
Top agency details / Agency name Department of Health and Human Services
Top agency details / Agency code HHS
Top agency details / Top agency code HHS
Forecast / Opportunity id 360679
Forecast / Version 2
Forecast / Posting date Sep 30, 2025 12:00:00 AM EDT
Forecast / Archive date Aug 30, 2026 12:00:00 AM EDT
Forecast / Forecast desc This NOFO requests limited competition applications for a 3-year extension of the COPE-AKI clinical trial consortium, which includes three clinical centers (CCs) and one scientific and data research center (SDRC), are requested to fully meet the enrollment targets, complete participant follow-up, and provide resources for data analysis and dissemination of study findings. There is currently no standard of care for patients after hospitalization with acute kidney injury (AKI). Successful completion of the COPE-AKI study will provide key insights that are expected to directly inform improved clinical management strategies and the development of standard of care for Stage 2 and 3 AKI survivors.
 
This is a forecast for a limited competition Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.
Forecast / Cost sharing No
Forecast / Number of awards 3
Forecast / Estimated funding 2500000
Forecast / Agency contact name Ivonne Schulman
Forecast / Agency contact phone 301-435-3350
Forecast / Agency contact email ivonne.schulman@nih.gov
Forecast / Agency contact email desc ivonne.schulman@nih.gov
Forecast / Agency code HHS-NIH11
Forecast / Applicant eligibility desc Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Forecast / Est synopsis posting date Apr 01, 2026 12:00:00 AM EDT
Forecast / Est application response date Jul 01, 2026 12:00:00 AM EDT
Forecast / Est award date Jan 01, 2027 12:00:00 AM EST
Forecast / Est project start date Feb 01, 2027 12:00:00 AM EST
Forecast / Fiscal year 2027
Forecast / Mod comments Updated Archive Date
Forecast / Create time stamp Aug 31, 2026 10:14:02 AM EDT
Forecast / Created date Sep 30, 2025 09:20:09 AM EDT
Forecast / Last updated date Aug 31, 2026 10:14:02 AM EDT
Forecast / Agency details / Code NIH
Forecast / Agency details / Seed HHS-NIH11
Forecast / Agency details / Agency name National Institutes of Health
Forecast / Agency details / Agency code HHS-NIH11
Forecast / Agency details / Top agency code HHS
Forecast / Estimated funding formatted 2,500,000
Forecast / Applicant types 1 / Id 13
Forecast / Applicant types 1 / Description Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Forecast / Applicant types 2 / Id 20
Forecast / Applicant types 2 / Description Private institutions of higher education
Forecast / Applicant types 3 / Id 08
Forecast / Applicant types 3 / Description Public housing authorities/Indian housing authorities
Forecast / Applicant types 4 / Id 23
Forecast / Applicant types 4 / Description Small businesses
Forecast / Applicant types 5 / Id 04
Forecast / Applicant types 5 / Description Special district governments
Forecast / Applicant types 6 / Id 22
Forecast / Applicant types 6 / Description For profit organizations other than small businesses
Forecast / Applicant types 7 / Id 07
Forecast / Applicant types 7 / Description Native American tribal governments (Federally recognized)
Forecast / Applicant types 8 / Id 25
Forecast / Applicant types 8 / Description Others (see text field entitled "Additional Information on Eligibility" for clarification)
Forecast / Applicant types 9 / Id 01
Forecast / Applicant types 9 / Description County governments
Forecast / Applicant types 10 / Id 06
Forecast / Applicant types 10 / Description Public and State controlled institutions of higher education
Forecast / Applicant types 11 / Id 11
Forecast / Applicant types 11 / Description Native American tribal organizations (other than Federally recognized tribal governments)
Forecast / Applicant types 12 / Id 00
Forecast / Applicant types 12 / Description State governments
Forecast / Applicant types 13 / Id 12
Forecast / Applicant types 13 / Description Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Forecast / Applicant types 14 / Id 02
Forecast / Applicant types 14 / Description City or township governments
Forecast / Applicant types 15 / Id 05
Forecast / Applicant types 15 / Description Independent school districts
Forecast / Funding instruments 1 / Id CA
Forecast / Funding instruments 1 / Description Cooperative Agreement
Forecast / Funding activity categories 1 / Id HL
Forecast / Funding activity categories 1 / Description Health
Forecast / Posting date str 2025-09-30-00-00-00
Forecast / Archive date str 2026-08-30-00-00-00
Forecast / Est synopsis posting date str 2026-04-01-00-00-00
Forecast / Est application response date str 2026-07-01-00-00-00
Forecast / Est award date str 2027-01-01-00-00-00
Forecast / Est project start date str 2027-02-01-00-00-00
Forecast / Create time stamp str 2026-08-31-10-14-02
Synopsis attachment folders 1 / Id 81207
Synopsis attachment folders 1 / Opportunity id 360679
Synopsis attachment folders 1 / Folder type Full Announcement
Synopsis attachment folders 1 / Folder name Full Announcement
Synopsis attachment folders 1 / Zip lob size 31294
Synopsis attachment folders 1 / Created date Aug 31, 2026 10:14:01 AM EDT
Synopsis attachment folders 1 / Last updated date Aug 31, 2026 10:14:02 AM EDT
Synopsis attachment folders 1 / Synopsis attachments 1 / Id 354873
Synopsis attachment folders 1 / Synopsis attachments 1 / Opportunity id 360679
Synopsis attachment folders 1 / Synopsis attachments 1 / Mime type text/html;charset=UTF-8
Synopsis attachment folders 1 / Synopsis attachments 1 / File name RFA-DK-27-125-Full-Announcement.html
Synopsis attachment folders 1 / Synopsis attachments 1 / File description RFA-DK-27-125-Full-Announcement.html
Synopsis attachment folders 1 / Synopsis attachments 1 / File lob size 140501
Synopsis attachment folders 1 / Synopsis attachments 1 / Created date Aug 31, 2026 10:14:02 AM EDT
Synopsis attachment folders 1 / Synopsis attachments 1 / Synopsis att folder id 81207
Synopsis document urls Not specified
Syn att change comments Not specified
Cfdas 1 / Id 431239
Cfdas 1 / Opportunity id 360679
Cfdas 1 / Cfda number 93.847
Cfdas 1 / Program title Diabetes, Digestive, and Kidney Diseases Extramural Research
Opportunity pkgs 1 / Id 294083
Opportunity pkgs 1 / Topportunity id 360679
Opportunity pkgs 1 / Family id 14
Opportunity pkgs 1 / Dialect XFDL2.2
Opportunity pkgs 1 / Opportunity number RFA-DK-27-125
Opportunity pkgs 1 / Opportunity title Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
Opportunity pkgs 1 / Cfda number 93.847
Opportunity pkgs 1 / Opening date 2026-10-06
Opportunity pkgs 1 / Closing date 2026-11-06
Opportunity pkgs 1 / Owning agency code HHS-NIH11
Opportunity pkgs 1 / Agency details / Code NIH
Opportunity pkgs 1 / Agency details / Seed HHS-NIH11
Opportunity pkgs 1 / Agency details / Agency name National Institutes of Health
Opportunity pkgs 1 / Agency details / Agency code HHS-NIH11
Opportunity pkgs 1 / Agency details / Top agency code HHS
Opportunity pkgs 1 / Top agency details / Code HHS
Opportunity pkgs 1 / Top agency details / Seed HHS
Opportunity pkgs 1 / Top agency details / Agency name Department of Health and Human Services
Opportunity pkgs 1 / Top agency details / Agency code HHS
Opportunity pkgs 1 / Top agency details / Top agency code HHS
Opportunity pkgs 1 / Program title Diabetes, Digestive, and Kidney Diseases Extramural Research
Opportunity pkgs 1 / Contact info eRA Service Desk
https://www.era.nih.gov/need-help
Opportunity pkgs 1 / Grace period 60
Opportunity pkgs 1 / Competition id FORMS-I
Opportunity pkgs 1 / Competition title Use for due date on or after January 25, 2025.
Opportunity pkgs 1 / Electronic required Y
Opportunity pkgs 1 / Expected application count 100
Opportunity pkgs 1 / Open to applicant type 1
Opportunity pkgs 1 / Is multi project N
Opportunity pkgs 1 / Extension pdf
Opportunity pkgs 1 / Mimetype application/pdf
Opportunity pkgs 1 / Last update Aug 31, 2026 10:14:37 AM EDT
Opportunity pkgs 1 / Workspace compatible flag Y
Opportunity pkgs 1 / Package id PKG00294083
Opportunity pkgs 1 / Opening date str 2026-10-06-00-00-00
Opportunity pkgs 1 / Closing date str 2026-11-06-00-00-00
Closed opportunity pkgs Not specified
Original due date Nov 06, 2026 12:00:00 AM EST
Synopsis modified fields Not specified
Forecast modified fields revision; version; archiveDate; modComments; createTimeStamp
Error messages Not specified
Syn post date in past Yes
Doc type synopsis
Forecast hist count 0
Synopsis hist count 0
Assist compatible No
Assist url Not specified
Related opps Not specified
Ost POSTED

Related Documents

There are no related documents on this grant.

Packages

Agency Contact Information: Division of Kidney, Urologic, and Hematologic Diseases
NIDDK_KUH@nih.gov
Assistance Listing Number Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions
93.847 FORMS-I Use for due date on or after January 25, 2025. PKG00294083 2026-10-06 2026-11-06 View

Package 1

Instructions

PKG00294120-instructions.pdf

Mandatory forms

RR_SF424_5_0-V5.0.pdf
PHS398_CoverPageSupplement_5_0-V5.0.pdf
RR_OtherProjectInfo_1_4-V1.4.pdf
PerformanceSite_4_0-V4.0.pdf
RR_KeyPersonExpanded_4_0-V4.0.pdf
PHS398_ResearchPlan_5_0-V5.0.pdf
PHSHumanSubjectsAndClinicalTrialsInfo_3_0-V3.0.pdf

Optional forms

RR_Budget_3_0-V3.0.pdf
RR_SubawardBudget30_3_0-V3.0.pdf
PHS398_ModularBudget_1_2-V1.2.pdf
PHS_AssignmentRequestForm_4_0-V4.0.pdf

osnqt2026-09-15T23:23:11-05:00

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