This grant, offered by the Medical Research Department, aims to support the development of improved, broad-spectrum products for treating Botulinum Neurotoxin (BoNT) intoxication. A primary focus is on therapies capable of reversing BoNT effects across multiple serotypes. This funding opportunity employs a unique milestone-driven, biphasic award mechanism. The initial R61 phase requires the achievement of specific, predetermined milestones for successful transition to the subsequent R33 phase. This structure ensures that only promising research demonstrating clear progress continues to receive funding, promoting the efficient development of effective anti-BoNT treatments.
Opportunity ID: 357668
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-24-080 |
| Funding Opportunity Title: | Broad Spectrum Products Against Multiple Neurotoxin Botulinum Serotypes (R61/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 11, 2024 |
| Last Updated Date: | Dec 11, 2024 |
| Original Closing Date for Applications: | May 02, 2025 |
| Current Closing Date for Applications: | May 02, 2025 |
| Archive Date: | Jun 07, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments Private institutions of higher education State governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support the development of improved products for treating Botulinum Neurotoxin (BoNT) intoxication. Development of products that can reverse BoNT intoxication are highly encouraged. This NOFO will use a milestone-driven, biphasic award mechanism. Transition to the R33 phase will depend on the successful completion of specific milestones during the R61 phase. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-080.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357668 Full Announcement-RFA-AI-24-080 -> RFA-AI-24-080-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289593 | Apr 02, 2025 | May 02, 2025 | View |
Package 1
Mandatory forms
357668 RR_SF424_5_0-5.0.pdf
357668 PHS398_CoverPageSupplement_5_0-5.0.pdf
357668 RR_OtherProjectInfo_1_4-1.4.pdf
357668 PerformanceSite_4_0-4.0.pdf
357668 RR_KeyPersonExpanded_4_0-4.0.pdf
357668 RR_Budget10_3_0-3.0.pdf
357668 PHS398_ResearchPlan_5_0-5.0.pdf
357668 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357668 RR_SubawardBudget10_30_3_0-3.0.pdf
357668 PHS_AssignmentRequestForm_4_0-4.0.pdf
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