The National Cancer Institute is offering a grant to support the development of technology tools to enhance research using next generation cancer models, such as organoids and reprogrammed cells. The focus is on facilitating the utilization of these models through improved laboratory methods, reagents, and bioinformatics tools. The goal is to accelerate the identification of therapeutic targets, resistance mechanisms, and biomarkers, ultimately advancing precision oncology. This grant is part of the Beau Biden Cancer Moonshot Initiative and aims to expedite the sharing and validation of results derived from next-gen cancer models. Closing date: Aug 30, 2019.
Opportunity ID: 317675
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-19-055 |
| Funding Opportunity Title: | Novel Technology Tools to Facilitate Research Using Next Generation Patient-derived Cancer Models (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.353 — 21st Century Cures Act – Beau Biden Cancer Moonshot |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 28, 2019 |
| Last Updated Date: | Jun 28, 2019 |
| Original Closing Date for Applications: | Aug 30, 2019 |
| Current Closing Date for Applications: | Aug 30, 2019 |
| Archive Date: | Oct 05, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $700,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Private institutions of higher education Small businesses Public housing authorities/Indian housing authorities State governments Independent school districts Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support the development of technology, tools that will facilitate, accelerate, and/or enhance research using advanced human-derived next generation cancer models, such as organoids, conditionally reprogrammed cells, and others. The studies proposed under this FOA must focus entirely on the next generation cancer models developed under the auspices of an international consortium with NCI participation, Human Cancer Models Initiative. “Technology tools” to be developed under this FOA may include new and/or optimized laboratory methods, reagents/reference materials, agents for NGCMs perturbation or screening read-outs, and/or software/bioinformatics tools for data processing and/or facilitated/enhanced interpretations. (The development of new hardware/equipment will not be supported). The proposed technology tools are expected to a) facilitate the utilization of the cancer models, e.g., in terms of increasing robustness, rigor, and/or reproducibility, b) enable advanced interpretations of experiments in which these model are used, c) design and test CRISPR reagents for all cancer and NGCM types, and d) develop robust approaches to method standardization, quality assurance/control, etc., that could serve as routine workflows/best practices for use in wide range of laboratories. The collective outcomes of projects under this FOA should facilitate the adoption of NGCMs by the research community and expedite sharing and validating of NGCMs-derived results. The new tools and broader use of NCGMs are expected to contribute to the progress in such areas as the identification of novel therapeutic targets, mechanisms of resistance, development of diagnostic and/or predictive biomarkers, and other aspects relevant to precision oncology. This FOA is associated with the Beau Biden Cancer Moonshot SM Initiative that is intended to accelerate cancer research. Specifically, this F |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-19-055.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00252464 | Jul 30, 2019 | Aug 30, 2019 | View |
Package 1
Mandatory forms
317675 RR_SF424_2_0-2.0.pdf
317675 PHS398_CoverPageSupplement_4_0-4.0.pdf
317675 RR_OtherProjectInfo_1_4-1.4.pdf
317675 PerformanceSite_2_0-2.0.pdf
317675 RR_KeyPersonExpanded_2_0-2.0.pdf
317675 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
317675 RR_Budget_1_4-1.4.pdf
317675 RR_SubawardBudget30_1_4-1.4.pdf
317675 PHS398_ModularBudget_1_2-1.2.pdf
317675 PHS_AssignmentRequestForm_2_0-2.0.pdf
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