This National Cancer Institute (NCI) grant aims to advance cancer model systems to improve immuno-oncology study predictivity. It focuses on accurately recapitulating human immunity in the tumor microenvironment. Research must use human cells/tissues to regenerate or replicate the human immune system in in vivo or in vitro models. These models need to achieve human immune system representation matching or exceeding current murine models developed with HFT. Projects solely using genetically manipulated immune systems without human immune lineage cells are ineligible. This opportunity utilizes the R33 Exploratory/Developmental Grants Phase II research activity code.
Opportunity ID: 351499
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-24-017 |
| Funding Opportunity Title: | Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 14, 2023 |
| Last Updated Date: | Dec 14, 2023 |
| Original Closing Date for Applications: | Nov 15, 2024 |
| Current Closing Date for Applications: | Nov 15, 2024 |
| Archive Date: | Dec 21, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses For profit organizations other than small businesses Special district governments City or township governments Public and State controlled institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this FOA is to advance cancer model systems that recapitulate human immunity in the tumor microenvironment to improve the predictivity of immuno-oncology studies. Proposed research projects must focus on recapitulation of the human immune system in their proposed cancer model using human cells or tissues to regenerate and/or recapitulate the human immune system in in vivo or in vitro immuno-oncology models in a manner that matches or exceeds representation of the human immune system achieved with murine models developed using HFT. Models derived from genetically manipulated immune systems without introduction of human immune lineage cells will not be considered responsive.The FOA will utilize the R33 Exploratory/Developmental Grants Phase II research activity code. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-24-017.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 351499 Full Announcement-RFA-CA-24-017 -> RFA-CA-24-017-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00284176 | May 11, 2024 | Nov 15, 2024 | View |
Package 1
Mandatory forms
351499 RR_SF424_5_0-5.0.pdf
351499 PHS398_CoverPageSupplement_5_0-5.0.pdf
351499 RR_OtherProjectInfo_1_4-1.4.pdf
351499 PerformanceSite_4_0-4.0.pdf
351499 RR_KeyPersonExpanded_4_0-4.0.pdf
351499 PHS398_ResearchPlan_5_0-5.0.pdf
351499 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
351499 RR_Budget_3_0-3.0.pdf
351499 RR_SubawardBudget30_3_0-3.0.pdf
351499 PHS398_ModularBudget_1_2-1.2.pdf
351499 PHS_AssignmentRequestForm_3_0-3.0.pdf
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