The National Cancer Institute (NCI) is offering this grant to support crucial basic and translational research for developing a prophylactic or therapeutic Kaposi Sarcoma Herpesvirus (KSHV) vaccine. This initiative aims to prevent primary KSHV infection, transmission, and subsequent diseases like Kaposi Sarcoma, multicentric Castleman disease, and primary effusion lymphoma, or to ameliorate existing KSHV disease. This grant is for advancing KSHV vaccine development, covering areas such as identifying potential vaccine targets, developing and testing prototype KSHV vaccines in animal models, optimizing efficacy for people with HIV (PWH), and refining KSHV detection methods to improve public health outcomes.
Opportunity ID: 350597
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-24-006 |
| Funding Opportunity Title: | Translational Research Toward Development of a Kaposi Sarcoma Herpesvirus (KSHV) Vaccine (U01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 16, 2023 |
| Last Updated Date: | Oct 16, 2023 |
| Original Closing Date for Applications: | Dec 04, 2024 |
| Current Closing Date for Applications: | Dec 04, 2024 |
| Archive Date: | Jan 09, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities City or township governments Private institutions of higher education County governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity Announcement (NOFO), the National Cancer Institute (NCI) intends to expand the research scope and leverage the gains made through the NOFO entitled Investigation of the Transmission of KSHV (RFA-CA-18-013 and RFA-CA-20-046) to support basic and translational research that will guide the development of a prophylactic or therapeutic Kaposi sarcoma herpesvirus (KSHV) vaccine. A prophylactic KSHV vaccine could prevent primary KSHV infection, transmission, and subsequent development of KS and other KSHV-associated syndromes such as multicentric Castleman disease (MCD), primary effusion lymphoma (PEL) and KSHV inflammatory cytokine syndrome (KICS) or ameliorate the severity of disease. A therapeutic KSHV vaccine could be helpful in preventing or treating KSHV disease in people who are already infected with KSHV. Research areas could include, but are not limited to: (1) Identification and evaluation of KSHV structural and non-structural targets for a potential KSHV vaccine; (2) Development of animal models to study a prototype KSHV vaccine or vaccines; (3) Development and testing of a candidate KSHV vaccine or vaccines; (4) Studies to assess how the efficacy of a promising KSHV vaccine can be optimized for PWH; (5) Research to better define the initial steps of infection with KSHV and the primary means of person-to-person transmission in different populations that can be targeted with a vaccine; and (6) Optimization and/or standardization of KSHV detection methods. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-24-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350597 Full Announcement-RFA-CA-24-006 -> RFA-CA-24-006-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00283478 | Nov 21, 2023 | Jan 24, 2025 | View |
Package 1
Mandatory forms
350597 RR_SF424_5_0-5.0.pdf
350597 PHS398_CoverPageSupplement_5_0-5.0.pdf
350597 RR_OtherProjectInfo_1_4-1.4.pdf
350597 PerformanceSite_4_0-4.0.pdf
350597 RR_KeyPersonExpanded_4_0-4.0.pdf
350597 PHS398_ResearchPlan_5_0-5.0.pdf
350597 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350597 RR_Budget_3_0-3.0.pdf
350597 RR_SubawardBudget30_3_0-3.0.pdf
350597 PHS398_ModularBudget_1_2-1.2.pdf
350597 PHS_AssignmentRequestForm_3_0-3.0.pdf
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