The National Cancer Institute (NCI) is offering this grant to fund the development of novel technologies critical for enhanced cancer detection and diagnosis. This grant is specifically for advancing methods to capture, enrich, and preserve exfoliated abnormal cells from body fluids or effusions, and to concentrate tumor-derived sub-cellular materials for biomarker studies. Routine cytopathology often struggles with the low number of atypical cells in specimens, limiting accurate detection. Therefore, the purpose of this funding opportunity is to spur innovation in new enrichment techniques. These advancements are necessary to facilitate the reliable detection of very low levels of tumor cells and their sub-cellular components in biological fluids, ultimately improving cancer diagnosis.
Opportunity ID: 48682
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-09-238 |
| Funding Opportunity Title: | Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 22, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2012 |
| Current Closing Date for Applications: | Sep 07, 2012 |
| Archive Date: | Oct 08, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose.This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), invites applications aimed at the development of novel technologies for capturing, enriching, and preserving exfoliated abnormal cells from body fluids or effusions as well as methods for concentrating the tumor-derived sub-cellular material for use in biomarker studies. In body fluids, such as sputum, exfoliated tumor cells are a minor component compared to normal cells. As a result, the detection of exfoliated abnormal cells by routine cytopathology is often limited by the low number of atypical cells present in a given specimen. New enrichment methods are necessary to facilitate the detection of very low levels of exfoliated tumor cells and tumor-derived sub-cellular materials in biological fluids. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and costs of the applications received. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-09-238.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B1 | Supersedes ADOBE-FORMS-B | PKG00022237 | Oct 30, 2010 | Sep 07, 2012 | View | |
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00013256 | Sep 16, 2009 | Feb 20, 2010 | View | |
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00015286 | Dec 21, 2009 | Oct 30, 2010 | View |
Package 1
Mandatory forms
48682 RR_SF424_1_2-1.2.pdf
48682 RR_OtherProjectInfo_1_3-1.3.pdf
48682 RR_KeyPersonExpanded_1_2-1.2.pdf
48682 PerformanceSite_1_4-1.4.pdf
48682 PHS398_ResearchPlan_1_3-1.3.pdf
48682 PHS398_CoverPageSupplement_1_4-1.4.pdf
48682 PHS398_Checklist_1_3-1.3.pdf
Optional forms
48682 RR_Budget-1.1.pdf
48682 RR_SubawardBudget-1.2.pdf
48682 PHS_CoverLetter_1_2-1.2.pdf
48682 PHS398_ModularBudget-1.1.pdf
Package 2
Mandatory forms
48682 RR_SF424-1.1.pdf
48682 RR_KeyPersonExpanded-1.1.pdf
48682 RR_OtherProjectInfo-1.1.pdf
48682 RR_PerformanceSite-1.1.pdf
48682 PHS398_CoverPageSupplement-1.1.pdf
48682 PHS398_ResearchPlan-1.1.pdf
48682 PHS398_Checklist-1.1.pdf
Optional forms
48682 PHS398_CoverLetter-1.1.pdf
48682 PHS398_ModularBudget-1.1.pdf
48682 RR_Budget-1.1.pdf
48682 RR_SubawardBudget-1.2.pdf
Package 3
Mandatory forms
48682 RR_SF424_1_2-1.2.pdf
48682 PerformanceSite_1_3-1.3.pdf
48682 RR_OtherProjectInfo_1_2-1.2.pdf
48682 RR_KeyPersonExpanded_1_2-1.2.pdf
48682 PHS398_CoverPageSupplement_1_4-1.4.pdf
48682 PHS398_ResearchPlan_1_3-1.3.pdf
48682 PHS398_Checklist_1_3-1.3.pdf
Optional forms
48682 PHS_CoverLetter_1_2-1.2.pdf
48682 PHS398_ModularBudget-1.1.pdf
48682 RR_Budget-1.1.pdf
48682 RR_SubawardBudget-1.2.pdf
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