The National Cancer Institute (NCI) is offering this grant to support the advanced development and rigorous validation of emerging biospecimen science technologies. This grant is for exploratory research projects focused on enhancing the quality and handling of samples crucial for basic and clinical cancer research. Supported technologies include tools, devices, assays, and methods for the collection, processing, preservation, and storage of cancer-relevant biospecimens, aiming to protect sample integrity, establish quality control criteria, and address pre-analytical degradation. Applicants should have overcome major feasibility gaps, providing preliminary data demonstrating the tool’s potential. These innovations are expected to accelerate research in cancer biology, early detection, diagnosis, treatment, epidemiology, and address health disparities, contributing to NCI’s Innovative Molecular Analysis Technologies (IMAT) Program.
Opportunity ID: 357737
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-25-004 |
| Funding Opportunity Title: | Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | 2 |
| Assistance Listings: | 93.394 — Cancer Detection and Diagnosis Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 16, 2024 |
| Last Updated Date: | Dec 16, 2024 |
| Original Closing Date for Applications: | Oct 03, 2025 |
| Current Closing Date for Applications: | Oct 03, 2025 |
| Archive Date: | Nov 08, 2025 |
| Estimated Total Program Funding: | $300,000 |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities City or township governments Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Native American tribal governments (Federally recognized) County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity (NOFO), National Cancer Institute (NCI) solicits grant applications proposing exploratory research projects focused on further development and validation of emerging technologies that improve the quality and handling of samples used for cancer research or clinical care. Through this NOFO, NCI will support the development of tools, devices, assays, and associated methods for the collection, handling, processing, preservation, or storage of cancer-relevant biospecimens and their derivatives. This includes tools with new capabilities to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and address issues related to pre-analytical degradation of of targeted analytes. Major feasibility gaps for the technology or methodology should have already been overcome, as demonstrated by supportive preliminary data, but the tool requires further development and rigorous validation. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection and screening, clinical diagnosis, treatment, or epidemiology and/or address issues associated with cancer health disparities. This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-25-004.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357737 Full Announcement-RFA-CA-25-004 -> RFA-CA-25-004-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289681 | Mar 04, 2025 | Oct 03, 2025 | View |
Package 1
Mandatory forms
357737 RR_SF424_5_0-5.0.pdf
357737 PHS398_CoverPageSupplement_5_0-5.0.pdf
357737 RR_OtherProjectInfo_1_4-1.4.pdf
357737 PerformanceSite_4_0-4.0.pdf
357737 RR_KeyPersonExpanded_4_0-4.0.pdf
357737 RR_Budget_3_0-3.0.pdf
357737 PHS398_ResearchPlan_5_0-5.0.pdf
357737 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357737 RR_SubawardBudget30_3_0-3.0.pdf
357737 PHS_AssignmentRequestForm_4_0-4.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
