This National Cancer Institute (NCI) grant supports fundamental research aimed at unraveling the intricate ways the human microbiome influences anti-tumor immune responses. The grant seeks to identify novel molecular targets for cancer prevention strategies. Eligible applications should precisely delineate how host interactions with specific microbes or their metabolites modulate immune responses, impacting either inflammation-associated or sporadic tumor formation. Research should explore the concentration, timing, and duration of administered beneficial microbes, acknowledging their potential to alter effectiveness. This funding opportunity is crucial for advancing our understanding of microbiome-mediated immunity and its implications for future cancer therapies and prevention.
Opportunity ID: 336394
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-061 |
| Funding Opportunity Title: | Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 03, 2021 |
| Last Updated Date: | Nov 03, 2021 |
| Original Closing Date for Applications: | Jan 07, 2025 |
| Current Closing Date for Applications: | Jan 07, 2025 |
| Archive Date: | Feb 12, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses State governments City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support basic research that elucidates mechanisms by which the human microbiome inhibit or enhance anti-tumor immune responses, and to identify potential novel molecular targets for cancer prevention strategies. Applications should be focused on delineating how host interactions with specific microbes (or consortia) or their metabolites targets immune responses that enhance or prevent inflammation-associated or sporadic tumor formation. Concentration, timing, and duration of administered beneficial microbes may alter its effectiveness and thus those parameters should be rigorously addressed in the application. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-061.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 336394 Full Announcement-PAR-22-061 -> PAR-22-061-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269982 | Jan 05, 2022 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00270168 | Jan 05, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00277790 | Nov 01, 2022 | Jan 24, 2025 | View |
Package 1
Mandatory forms
336394 RR_SF424_2_0-2.0.pdf
336394 PHS398_CoverPageSupplement_5_0-5.0.pdf
336394 RR_OtherProjectInfo_1_4-1.4.pdf
336394 PerformanceSite_2_0-2.0.pdf
336394 RR_KeyPersonExpanded_2_0-2.0.pdf
336394 PHS398_ResearchPlan_4_0-4.0.pdf
336394 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336394 RR_Budget_1_4-1.4.pdf
336394 RR_SubawardBudget30_1_4-1.4.pdf
336394 PHS398_ModularBudget_1_2-1.2.pdf
336394 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336394 RR_SF424_5_0-5.0.pdf
336394 PHS398_CoverPageSupplement_5_0-5.0.pdf
336394 RR_OtherProjectInfo_1_4-1.4.pdf
336394 PerformanceSite_4_0-4.0.pdf
336394 RR_KeyPersonExpanded_4_0-4.0.pdf
336394 PHS398_ResearchPlan_4_0-4.0.pdf
336394 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336394 RR_Budget_3_0-3.0.pdf
336394 RR_SubawardBudget30_3_0-3.0.pdf
336394 PHS398_ModularBudget_1_2-1.2.pdf
336394 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
336394 RR_SF424_5_0-5.0.pdf
336394 PHS398_CoverPageSupplement_5_0-5.0.pdf
336394 RR_OtherProjectInfo_1_4-1.4.pdf
336394 PerformanceSite_4_0-4.0.pdf
336394 RR_KeyPersonExpanded_4_0-4.0.pdf
336394 PHS398_ResearchPlan_5_0-5.0.pdf
336394 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336394 RR_Budget_3_0-3.0.pdf
336394 RR_SubawardBudget30_3_0-3.0.pdf
336394 PHS398_ModularBudget_1_2-1.2.pdf
336394 PHS_AssignmentRequestForm_3_0-3.0.pdf
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