The National Cancer Institute is offering grants for Research Programs under the Pediatric Preclinical Testing Consortium (PPTC) initiative. This grant aims to conduct in vivo and in vitro testing of pediatric anticancer drug candidates to establish a robust preclinical testing system. Applicants can focus on specific tumor types relevant to pediatric oncology, such as leukemia, central nervous system tumors, and other solid tumors. The Research Programs should be capable of assessing tumor regression and time to event for new agents annually. Collaboration with the PPTC Coordinating Center is required for successful applicants. Closing date for applications is Nov 13, 2014.
Opportunity ID: 264192
General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | RFA-CA-14-018 |
| Funding Opportunity Title:: | Pediatric Preclinical Testing Consortium: Research Programs (U01) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Education |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 93.395 — Cancer Treatment Research |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 2 |
| Posted Date:: | Sep 05, 2014 |
| Last Updated Date:: | Sep 05, 2014 |
| Original Closing Date for Applications:: | Nov 13, 2014 |
| Current Closing Date for Applications:: | Nov 13, 2014 |
| Archive Date:: | Dec 14, 2014 |
| Estimated Total Program Funding:: | |
| Award Ceiling:: | $ |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | This Funding Opportunity Announcement (FOA) is for Research Programs for in vivo and in vitro testing of the activity of pediatric anticancer drug candidates. These Research Programs are the fundamental part of the Pediatric Preclinical Testing Consortium (PPTC) initiative, which also includes a PPTC Coordinating Center (supported under RFA-CA-14-019). The main goal for PPTC is to develop a rigorous preclinical testing system for pediatric anticancer drug candidates and to generate reliable data that can be used to inform new agent prioritization decisions. This FOA invites applications for drug testing Research Programs focused on specific tumor types that are particularly relevant to pediatric oncology. Each application must propose only one testing Research Program from the following four types:Type A: Research Program for leukemia in vivo testing;Type B: Research Program for tumors of central nervous system (CNS) in vivo testing; Type C: Research Program for other (non-CNS) solid tumors testing in vivo; and Type D: Research Program for in vitro testing.Applicants may propose Research Programs of more than one type but only through separate applications for each. Applicants proposing in vivo testing programs must be capable of quantitative assessment of tumor regression and time to event for 6 to 10 new agents (or combinations of agents) annually across relevant, well-characterized preclinical models. All applicants are expected to have substantial expertise regarding the biology and therapeutic opportunities for the tumor types that they propose to study. The PPTC Research Program Awardees will be required to collaborate closely with the PPTC Coordinating Center. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 2 | Corrected Eligible Applicants field | Sep 05, 2014 |
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | |
| Competition ID: | FORMS-C |
| Competition Title: | FORMS-C |
| Opportunity Package ID: | PKG00205224 |
| Opening Date: | Oct 13, 2014 |
| Closing Date: | Nov 13, 2014 |
| Agency Contact Information:: | eRA Commons Help Desk |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0] |
| optional_forms |
R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3] |
Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00205224 | Oct 13, 2014 | Nov 13, 2014 | View | eRA Commons Help Desk | Organization Applicants |