The National Eye Institute (NEI) is offering this grant to support collaborative studies aimed at discovering the underlying pathophysiology of Age-related Macular Degeneration (AMD). This grant is for researchers to utilize a unique resource of patient-derived induced pluripotent stem cell (iPSC) lines, generated by the NEI’s AMD Integrative Biology Initiative. This comprehensive resource includes iPSC-derived retinal pigment epithelium (RPE) cells, along with corresponding clinical, genomic, and imaging data from AMD patients carrying high prevalence risk alleles from the AREDS2 study. The funding encourages projects that determine how these iPSC-derived cell lines can unveil AMD’s mechanisms, fostering collaborative efforts among investigators with diverse expertise.
Opportunity ID: 336578
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-EY-21-002 |
| Funding Opportunity Title: | Age-related Macular Degeneration (AMD) Integrative Biology Initiative: Discovery of AMD Pathobiology using Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE) (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.867 — Vision Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 17, 2021 |
| Last Updated Date: | Nov 17, 2021 |
| Original Closing Date for Applications: | Feb 17, 2022 |
| Current Closing Date for Applications: | Feb 17, 2022 |
| Archive Date: | Mar 25, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) aims to support collaborative studies of a unique resource of patient-derived induced pluripotent stem cell (iPSC) lines generated by the NEI age-related macular degeneration (AMD) Integrative Biology Initiative. This resource also includes clinical, genomic, and imaging data from the patients from which these cells were derived, and a set of isogenic control cell lines in which the risk allele(s) have been corrected. These cell lines and clinical data are from patients with AMD carrying high prevalence risk alleles selected from the Age-Related Eye Disease Study 2 (AREDS2). The goal of this FOA is to determine if these iPSC-derived cell lines can be used to discover the underlying pathophysiology of AMD. Collaborative effort is highly encouraged with investigators bringing in the needed areas of expertise for successful projects. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-21-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 336578 Full Announcement-RFA-EY-21-002 -> RFA-EY-21-002-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270452 | Jan 14, 2022 | Feb 17, 2022 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00270378 | Jan 14, 2022 | Jan 24, 2022 | View |
Package 1
Mandatory forms
336578 RR_SF424_5_0-5.0.pdf
336578 PHS398_CoverPageSupplement_5_0-5.0.pdf
336578 RR_OtherProjectInfo_1_4-1.4.pdf
336578 PerformanceSite_4_0-4.0.pdf
336578 RR_KeyPersonExpanded_4_0-4.0.pdf
336578 PHS398_ResearchPlan_4_0-4.0.pdf
336578 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336578 RR_Budget_3_0-3.0.pdf
336578 RR_SubawardBudget30_3_0-3.0.pdf
336578 PHS398_ModularBudget_1_2-1.2.pdf
336578 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336578 RR_SF424_2_0-2.0.pdf
336578 PHS398_CoverPageSupplement_5_0-5.0.pdf
336578 RR_OtherProjectInfo_1_4-1.4.pdf
336578 PerformanceSite_2_0-2.0.pdf
336578 RR_KeyPersonExpanded_2_0-2.0.pdf
336578 PHS398_ResearchPlan_4_0-4.0.pdf
336578 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336578 RR_Budget_1_4-1.4.pdf
336578 RR_SubawardBudget30_1_4-1.4.pdf
336578 PHS398_ModularBudget_1_2-1.2.pdf
336578 PHS_AssignmentRequestForm_3_0-3.0.pdf
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