National Institute of Allergy and Infectious Diseases – Clinical Trials in Organ Transplantation (CTOT) (U01)

This department is supporting a grant program aimed at improving the long-term outcomes of thoracic organ, abdominal organ, and vascular composite tissue transplant recipients. The Clinical Trials in Organ Transplantation (CTOT) program seeks to fund interventional and observational studies focusing on immune-mediated processes in allotransplantation and mechanisms of immune activation. The goal is to identify and address immune-mediated causes of morbidity and mortality in transplant recipients. Applications from groups of two or more institutions are encouraged to participate in this cooperative, multi-institutional consortium to advance research in organ and vascularized composite allotransplantation.

Opportunity ID: 237976

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	RFA-AI-13-006
Funding Opportunity Title::	Clinical Trials in Organ Transplantation (CTOT) (U01)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.855 — Allergy, Immunology and Transplantation Research
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 1
Posted Date::	Jul 19, 2013
Last Updated Date::
Original Closing Date for Applications::	Nov 19, 2013
Current Closing Date for Applications::	Nov 19, 2013
Archive Date::	Dec 20, 2013
Estimated Total Program Funding::	$ 9,500,000
Award Ceiling::	$1,750,000
Award Floor::	$

Eligibility

Eligible Applicants::

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	This FOA invites applications from groups of two (2) or more institutions to participate in a clinical studies program to improve the long-term outcome of transplant recipients (thoracic organ, abdominal organ and vascular composite tissue). The Clinical Trials in Organ Transplantation (CTOT) program will support a cooperative, multi-institutional consortium for the conduct of interventional trials (Phase 1, 2, or 3) or observational clinical studies in organ or vascularized composite allotransplantation (VCA). Each clinical study must include associated mechanistic studies that focus on immune-mediated pathologic processes in allotransplantation or on mechanisms of immune activation and quiescence. The goals of this research will be to target immune-mediated causes of morbidity and mortality in transplant recipients and evaluate interventions to address them.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:
Competition ID:	FORMS-C
Competition Title:	Forms-C
Opportunity Package ID:	PKG00181350
Opening Date:	Oct 19, 2013
Closing Date:	Nov 19, 2013
Agency Contact Information::	eRA Commons Help Desk
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3]