This National Institute of Allergy and Infectious Diseases (NIAID) grant seeks to leverage existing well-characterized T cell allergen epitopes to study allergen-specific immune responses. The primary focus is on conducting mechanistic studies to understand the progression and changes in severity of seasonal or perennial allergic diseases, such as allergic rhinitis or asthma, and the effects of therapeutic interventions like immunotherapy. Programs should concentrate on elucidating T cell phenotypes, their function, and their role in allergen-specific T-cell memory. While supporting novel T cell allergen epitope identification is limited, it is permissible as a companion to and extension of ongoing mechanistic studies of T cell responses to established allergen epitopes.
Opportunity ID: 86153
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-11-013 |
| Funding Opportunity Title: | Allergen Epitope Research and Validation Cnters (U19) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 07, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jul 22, 2011 |
| Current Closing Date for Applications: | Jul 22, 2011 |
| Archive Date: | Aug 22, 2011 |
| Estimated Total Program Funding: | $2,800,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses County governments State governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign (non-U.S.) components of U.S. Organizations are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this FOA is to capitalize on the availability of well characterized T cell allergen epitopes to study allergen-specific immune responses.. As part of the characterization and validation of these allergen T cell epitopes, there is a need to conduct mechanistic studies that focus on the progression and/or changes in the severity of seasonal or perennial allergic diseases (e.g. seasonal allergic rhinitis, asthma exacerbations triggered by pet dander), as well as the changes resulting from therapeutic intervention in allergic disease, such as immunotherapy for seasonal, perennial, or food allergies. Programs should focus on mechanistic assessment of T cell allergen epitopes to illuminate the T cell phenotypes, their function and contribution to allergen-specific T-cell memory. Limited novel T cell allergen epitope identification will also be supported under this FOA, but only as a companion to, and extension of, mechanistic studies of T cell responses to existing allergen epitopes. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-013.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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