National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant: Genetic Variant Analysis for Arthritis and Skin Diseases (R21)

This grant aims to support research projects that investigate the genetic variations in human genomic regions associated with complex diseases relevant to NIAMS. The goal is to identify causal genes and variants influencing disease risk and gain insights into their functions and disease mechanisms. The focus is on conducting follow-up studies of genetic variants, particularly those identified through genome-wide association studies, to advance biological understanding and potentially lead to diagnostic and therapeutic advancements. Applications should be exploratory and innovative, accelerating the translation of GWAS findings into actionable insights. Deadline for submission is February 20, 2014.

Opportunity ID: 182633

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	PAR-12-230
Funding Opportunity Title::	Identification and Analysis of Causal Variants: Follow-Up on Genome-Wide Association Studies for Arthritis and Musculoskeletal and Skin Diseases (R21)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.846 — Arthritis, Musculoskeletal and Skin Diseases Research
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 2
Posted Date::	Jul 10, 2012
Last Updated Date::	Jul 25, 2013
Original Closing Date for Applications::	Nov 20, 2013
Current Closing Date for Applications::	Feb 20, 2014
Archive Date::	Mar 20, 2014
Estimated Total Program Funding::
Award Ceiling::	$200,000
Award Floor::	$

Eligibility

Eligible Applicants::

County governments

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	This Funding Opportunity Announcement (FOA), issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, encourages applications that are exploratory/developmental and highly innovative in nature, and aim to characterize the genetic variations in human genomic regions that have been putatively associated with complex diseases relevant to the NIAMS mission. The purpose is to accelerate the discovery of causal genes and variants that influence the risk for disease; and conduct follow-up studies of particular genetic variants to gain novel insights into the functions of these variants and the mechanisms by which they may contribute to disease. Genomic regions of interest are primarily those identified by genome-wide association studies (GWAS) although other types of evidence may also inform the rationale for a given study. These studies are essential for the translation of initial GWAS finding into biological insights, and ultimately important for improving our understanding of the molecular mechanisms of disease that could lead to predictive, diagnostic, and therapeutic advances.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 2	Modified Archive Date based on new Expiration Date, per NOT-AR-13-023.	Jul 25, 2013
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:	93.846
Competition ID:	ADOBE-FORMS-B2
Competition Title:	ADOBE-FORMS-B2
Opportunity Package ID:	PKG00131290
Opening Date:	Oct 20, 2012
Closing Date:	Sep 24, 2013
Agency Contact Information::	Grants Info
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2]