This department is offering a grant to research the genetic basis of variability in drug responses for individuals with orofacial pain. The objective includes studying genetic variability in pharmacokinetics, pharmacodynamics, and drug toxicities to predict clinical outcomes of analgesic treatments. Researchers will focus on identifying genetic variations in drug metabolizing enzymes, transporters, drug targets, and signaling pathway molecules. The grant aims to identify molecular signatures for predicting therapeutic responses and encourage multidisciplinary collaboration. The ultimate goal is to personalize analgesic therapy for patients with acute and chronic orofacial pain. Researchers in clinical and basic sciences are encouraged to apply and explore new pharmacogenomics studies in chronic pain conditions related to orofacial pain.
Opportunity ID: 271190
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DE-16-001 |
| Funding Opportunity Title: | Pharmacogenomics of Orofacial Pain Management (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 08, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jun 24, 2015 |
| Current Closing Date for Applications: | Jun 24, 2015 |
| Archive Date: | Jul 25, 2015 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Independent school districts Native American tribal governments (Federally recognized) City or township governments State governments County governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this funding opportunity announcement (FOA) is to encourage research on the genetic basis of variability in therapeutic drug responses and adverse events in individuals with painful conditions of the dental, and orofacial region. The objectives are to determine the role of genetic variability in pharmacokinetics, pharmacodynamics, and drug toxicities that contribute to and predict the clinical outcomes of analgesic treatment of individuals with acute and chronic pain conditions. Delineation of genetic variation in drug and neurotransmitter metabolizing enzymes and transporters, drug target molecules such as enzymes and receptors, and associated post-receptor intracellular signaling pathway molecules is an important outcome of this FOA. Identification of key molecular signatures that are predictive of a therapeutic response is a second objective. Clinical and basic science researchers are encouraged to form multidisciplinary teams to effectively address the goals of this FOA. The ability to categorize individuals who differ in their responses to analgesic therapy will aid health care providers in their ability to prescribe the best treatments for acute and chronic pain patients with a personalized/ precision approach. Although this FOA is focused on orofacial pain, it also may serve as a catalyst for the pain research community to explore new pharmacogenomics studies in chronic pain conditions that overlap with temporomandibular joint disorder. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-16-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00211477 | May 24, 2015 | Jun 24, 2015 | View |
Package 1
Mandatory forms
271190 RR_SF424_2_0-2.0.pdf
271190 PHS398_ResearchPlan_2_0-2.0.pdf
271190 PHS398_CoverPageSupplement_2_0-2.0.pdf
271190 RR_KeyPersonExpanded_2_0-2.0.pdf
271190 RR_OtherProjectInfo_1_3-1.3.pdf
271190 PerformanceSite_2_0-2.0.pdf
Optional forms
271190 RR_SubawardBudget30_1_3-1.3.pdf
271190 PlannedReport-1.0.pdf
271190 PHS398_CumulativeInclusionReport-1.0.pdf
271190 PHS398_ModularBudget_1_2-1.2.pdf
271190 RR_Budget_1_3-1.3.pdf
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