This grant from the National Institute of Diabetes and Digestive and Kidney Diseases aims to fund projects enhancing the understanding of the physical and functional organization of the human islet tissue environment. It seeks to analyze the composition, function, and communication within the pancreatic tissue ecosystem. Projects will integrate the Human Pancreas Analysis Consortium (HPAC) with the Human Pancreas Analysis Program, focusing on human tissue structure, function, and disease biology related to T1D. The grant does not support clinical trials and emphasizes human research over animal models. Closing date for applications is May 10, 2018.
Opportunity ID: 300724
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-17-022 |
| Funding Opportunity Title: | High-Resolution Exploration of the Human Islet Tissue Environment [HIRN Human Pancreas Analysis Consortium (HPAC)] (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 15, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 10, 2018 |
| Current Closing Date for Applications: | May 10, 2018 |
| Archive Date: | Jun 15, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $550,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Special district governments Public and State controlled institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the physical and functional organization of the human islet tissue environment by describing the composition (cellular and molecular) and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and/or the contribution of adjacent (including acinar, ductal, lymphatic) and neighboring (intestinal, mesenteric and adipose) tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC), that will consist of the research teams funded in response to this FOA with the Human Pancreas Analysis Program (HPAP), a resource-generation program that was funded in 2016 in response to RFA-DK-15-027. HPAC will become the fifth consortium of the Human Islet Research Network (HIRN, https://hirnetwork.org/ ). HIRN’s overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology (as opposed to rodent or other animal models). This FOA is not intended to support the conduct of a clinical trial. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00238304 | Apr 10, 2018 | May 10, 2018 | View |
Package 1
Mandatory forms
300724 RR_SF424_2_0-2.0.pdf
300724 PHS398_CoverPageSupplement_4_0-4.0.pdf
300724 RR_OtherProjectInfo_1_4-1.4.pdf
300724 PerformanceSite_2_0-2.0.pdf
300724 RR_KeyPersonExpanded_2_0-2.0.pdf
300724 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
300724 RR_Budget_1_4-1.4.pdf
300724 RR_SubawardBudget30_1_4-1.4.pdf
300724 PHS398_ModularBudget_1_2-1.2.pdf
300724 PHS_AssignmentRequestForm_2_0-2.0.pdf
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