NIH is offering a grant to develop approaches to characterize candidate functional elements identified by the ENCODE project. This grant aims to determine the biological roles of these elements in specific contexts, such as using assays to test their function and evaluating their impact on genetic variants. Awardees will collaborate to assess the performance of funded assays and identify well-characterized functional elements in healthy or diseased states. The goal is to enhance understanding of functional characterization approaches and their application in investigating genetic variation in human diseases. Projects funded will be part of the ENCODE Consortium.
Opportunity ID: 281021
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-16-003 |
| Funding Opportunity Title: | Characterizing the Functional Elements in the Encyclopedia of DNA Elements (ENCODE) Catalog (UM1) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 15, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 21, 2016 |
| Current Closing Date for Applications: | Mar 21, 2016 |
| Archive Date: | Apr 21, 2016 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Small businesses For profit organizations other than small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities City or township governments Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA seeks applications to develop and apply generalizable approaches to characterize the role of candidate functional elements identified by the ENCyclopedia Of DNA Elements (ENCODE) in specific biological contexts.ENCODE has identified different classes of candidate functional regions based on their correlation with biochemical signatures, but has not tested the majority of those to determine what, if any, biological roles they actually play.This FOA solicits activities that include employing one or more assays to characterize the biological function of candidate elements, testing the impact of natural or engineered genetic variants on element function, or using human diseases or biological systems as test cases to evaluate the approaches. Awardees will also work together to characterize the strengths and weaknesses of the collection of assays funded by comparing their performance, and to identify a set of well-characterized functional elements in healthy and/or disease states. These products are expected to provide an understanding of the utility and generalizability of functional characterization approaches, and to facilitate investigation of the role of genetic variation in human disease. The funded projects will participate in the ENCODE Consortium. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-16-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00220502 | Feb 21, 2016 | Mar 21, 2016 | View |
Package 1
Mandatory forms
281021 RR_SF424_2_0-2.0.pdf
281021 PHS398_ResearchPlan_2_0-2.0.pdf
281021 PHS398_CoverPageSupplement_2_0-2.0.pdf
281021 RR_Budget_1_3-1.3.pdf
281021 RR_KeyPersonExpanded_2_0-2.0.pdf
281021 RR_OtherProjectInfo_1_3-1.3.pdf
281021 PerformanceSite_2_0-2.0.pdf
Optional forms
281021 PlannedReport-1.0.pdf
281021 PHS398_CumulativeInclusionReport-1.0.pdf
281021 RR_SubawardBudget30_1_3-1.3.pdf
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