National Institute of Mental Health Grant: Advancing Novel Treatments for Psychiatric Disorders (U01)

This department is offering a grant to conduct experimental medicine-based first in human (FIH) and proof of concept (POC) studies on new mechanism of action compounds for treating mental disorders. The grant aims to accelerate the development of innovative pharmacological treatments by supporting early phase human clinical testing. Researchers will assess target engagement, pharmacological effects, safety, and tolerability of novel compounds to build a pipeline for further clinical trials. The goal is to de-risk novel treatments and attract private funding for their development. Collaboration between academia and industry is encouraged. Closing date for applications is on Jan 07, 2012.

Opportunity ID: 115453

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	PAR-11-316
Funding Opportunity Title::	Innovative Pilot Studies of Novel Mechanism of Action Compounds for Treating Psychiatric Disorders (U01)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.242 — Mental Health Research Grants
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 2
Posted Date::	Aug 18, 2011
Last Updated Date::	Nov 07, 2011
Original Closing Date for Applications::	Sep 07, 2014
Current Closing Date for Applications::	Jan 07, 2012
Archive Date::	Feb 07, 2012
Estimated Total Program Funding::
Award Ceiling::	$
Award Floor::	$

Eligibility

Eligible Applicants::

City or township governments

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	The purpose of this Funding Opportunity Announcement (FOA) is to encourage cooperative agreement grant applications to support experimental medicine-based first in human (FIH) and proof of concept (POC) studies of new mechanism of action, IND-ready candidate medications to treat mental disorders. The objective of the FOA is to accelerate the development of innovative pharmacological treatments through support of early phase human clinical testing. FIH pharmacology studies should assess target engagement, pharmacological effects, safety, and tolerability of novel compounds in order to build a pipeline for initial POC or efficacy trials in patients. POC studies of novel compounds should use pharmacologically based dosing, with assessment of target engagement and evaluation of the impact of compounds on clinically relevant physiological systems as well as clinical indicators of effect. The overall objective is to facilitate rapid collection of data to “de-risk” novel mechanism of action or combination treatments and to attract private funding for further clinical and commercial development of candidate medications. Partnerships between academia and industry are strongly encouraged.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 2	Modified Archive Date based on new Expiration Date, per NOT-MH-12-002.	Nov 07, 2011
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:	93.242
Competition ID:	ADOBE-FORMS-B2
Competition Title:	ADOBE-FORMS-B2
Opportunity Package ID:	PKG00072830
Opening Date:	Sep 05, 2011
Closing Date:	Jan 07, 2012
Agency Contact Information::	Grants Info
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2]