This grant from the National Institute of Mental Health aims to fund the optimization and evaluation of neurophysiological and behavioral measures in animals for early screening in treatment development. By focusing on circuit engagement and neurobiological mechanisms of mental illnesses, this funding opportunity supports basic and translational neuroscientists in enhancing the efficiency of therapeutic pipelines. The goal is to establish in vivo assays as tools for target validation and therapeutic screening, with the potential for translatability to human studies in the future. Applications should contribute to building a robust suite of measures for evaluating novel therapeutic agents in early phases of development.
Opportunity ID: 310020
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-19-235 |
| Funding Opportunity Title: | Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 30, 2018 |
| Last Updated Date: | Oct 30, 2018 |
| Original Closing Date for Applications: | Feb 04, 2019 |
| Current Closing Date for Applications: | Feb 04, 2019 |
| Archive Date: | Mar 12, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments County governments Public housing authorities/Indian housing authorities Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The overall goal of this Funding Opportunity Announcement (FOA) is to identify, in animals, in vivo neurophysiological and behavioral measures for use as assays in the early screening phase of treatment development. The FOA will support efforts to optimize and evaluate measures of neurophysiological and behavioral processes that may serve as surrogate markers of neural processes of clinical interest based on available knowledge of the neurobiology of mental illnesses. The screening assays thus developed from this FOA are expected to build upon systems neurobiology and clinical neuroscience to enhance the scientific value of preclinical animal data contributing to a therapeutic development pipeline by assessing the impact of therapeutic targets and treatment candidates on neurobiological mechanisms of clinical relevance to mental illnesses. The objectives of the FOA will be accomplished by supporting basic and translational neuroscientists who are committed to improving the efficiency and scientific value of the therapeutic development pipeline by advancing the discovery of in vivo physiological and behavioral measures reflecting circuit engagement as tools for early phase target validation and therapeutic screening for mental illness treatment development. The efforts supported by this initiative focus on measures in animals as a first step in generating translational assay measures that are adaptable across early therapeutic screens in animals to evaluation in humans. As such, this FOA may be considered a prequel to build a suite of assays that are evaluated in future projects for coherence of assay performance between the preclinical species and healthy humans (see PAR-16-065; Novel Assays to Address Translational Gaps in Treatment Development (UG3/UH3)). In summary, this FOA will support efforts to improve the tool kit of assays available for early phase testing of novel therapeutic agents by incorporating measures proximal to neural systems that impact mental h |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-19-235.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00245972 | Jan 04, 2019 | Feb 04, 2019 | View |
Package 1
Mandatory forms
310020 RR_SF424_2_0-2.0.pdf
310020 PHS398_CoverPageSupplement_4_0-4.0.pdf
310020 RR_OtherProjectInfo_1_4-1.4.pdf
310020 PerformanceSite_2_0-2.0.pdf
310020 RR_KeyPersonExpanded_2_0-2.0.pdf
310020 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
310020 RR_Budget_1_4-1.4.pdf
310020 RR_SubawardBudget30_1_4-1.4.pdf
310020 PHS398_ModularBudget_1_2-1.2.pdf
310020 PHS_AssignmentRequestForm_2_0-2.0.pdf
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