This grant, offered by the National Institute of Mental Health, is for identifying and optimizing neurophysiological measures as potential assays to advance mental disorder treatment development. It supports studies evaluating these processes in humans and relevant animal species, focusing on those disrupted in mental disorders. The purpose is to develop preclinical assays for new drug and device therapies, and to identify where preclinical animal findings might not directly translate to humans. Ultimately, this initiative aims to improve the efficiency of therapeutic development, bridge the gap between preclinical screening and clinical evaluation, and accelerate the creation of more effective treatments for mental health conditions.
Opportunity ID: 357284
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-034 |
| Funding Opportunity Title: | Novel Assays to Address Translational Gaps in Treatment Development (UG3/UH3 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 21, 2024 |
| Last Updated Date: | Nov 21, 2024 |
| Original Closing Date for Applications: | Jun 20, 2025 |
| Current Closing Date for Applications: | Jun 20, 2025 |
| Archive Date: | Jul 26, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education City or township governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | SRF Reissue: The overall goal of this initiative is to identify neurophysiological measures potential assays for treatment development research. The Notice of Funding Opportunity (NOFO) will support efforts to optimize and evaluate measures of neurophysiological processes that are disrupted within or across mental disorders in both healthy humans and in another species relevant to the therapeutic development pipeline. The initiative will support initial proof of concept studies aimed at identifying measures for potential development as preclinical assays for evaluating potential new drug and device therapies and their targets. Data will also reveal assay measures where the performance between preclinical animal species and humans is dissimilar, thus establishing a firm basis for limiting speculative extrapolations of preclinical animal findings to humans. The ultimate practical goal of this NOFO is to improve the efficiency of the therapeutic development process by identifying coherence of measures and inconsistencies between the preclinical screening pipeline and clinical evaluation of new treatment candidates and thereby hasten the development of more effective treatments for mental disorders. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-034.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288866 | Jan 21, 2025 | Jun 20, 2025 | View |
Package 1
Mandatory forms
357284 RR_SF424_5_0-5.0.pdf
357284 PHS398_CoverPageSupplement_5_0-5.0.pdf
357284 RR_OtherProjectInfo_1_4-1.4.pdf
357284 PerformanceSite_4_0-4.0.pdf
357284 RR_KeyPersonExpanded_4_0-4.0.pdf
357284 RR_Budget10_3_0-3.0.pdf
357284 PHS398_ResearchPlan_5_0-5.0.pdf
357284 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357284 RR_SubawardBudget10_30_3_0-3.0.pdf
357284 PHS_AssignmentRequestForm_4_0-4.0.pdf
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