National Institute of Mental Health (NIMH) and National Institute of Neurological Disorders and Stroke (NINDS) Grant: Eradicating HIV-1 from CNS Reservoirs (R21)

This grant is aimed at funding innovative research to eradicate HIV-1 from central nervous system (CNS) reservoirs in individuals on HAART. Research areas include identifying CNS-based cellular reservoirs, understanding mechanisms of establishment and resurgence, developing relevant animal models and assays, screening drugs that penetrate the blood-brain barrier, and designing therapeutic strategies for HIV-1 eradication. Basic to translational research in domestic and international settings is encouraged. Multidisciplinary research teams are welcome to apply. Closing date for applications is September 12, 2012.

Opportunity ID: 144854

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	RFA-MH-13-031
Funding Opportunity Title::	Eradication of HIV-1 from CNS Reservoirs: Implications for Therapeutics (R21)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.242 — Mental Health Research Grants
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 1
Posted Date::	Feb 17, 2012
Last Updated Date::
Original Closing Date for Applications::	Sep 12, 2012
Current Closing Date for Applications::	Sep 12, 2012
Archive Date::	Oct 13, 2012
Estimated Total Program Funding::
Award Ceiling::	$200,000
Award Floor::	$

Eligibility

Eligible Applicants::

City or township governments

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	The National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) invite novel research grant applications to address the problem of HIV-1 persistence focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy (HAART). This Funding Opportunity Announcement (FOA) will support highly innovative research in five areas: (1) basic research to identify and characterize CNS-based cellular reservoirs of HIV-1 for individuals on HAART; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of CNS-based HIV-1 reservoirs in relationship to the effects and timing of HAART, viral expression, and viral evolution within the brain; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective HAART; (4) drug screening of potential agents which traverse the blood-brain barrier and eliminate latent or other sources of residual virus in the CNS; and (5) design of therapeutic strategies aimed at eradication of HIV-1 from the CNS. Applications ranging from basic to translational research in domestic and international settings are of interest. Multidisciplinary research teams are encouraged but not required.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:
Competition ID:	ADOBE-FORMS-B2
Competition Title:	ADOBE-FORMS-B2
Opportunity Package ID:	PKG00098251
Opening Date:	Aug 12, 2012
Closing Date:	Sep 12, 2012
Agency Contact Information::	Grants Info
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2]