National Institute on Aging: Dose Response and Efficacy Studies on Vitamin D Supplementation in Elderly (U01)

The National Institute on Aging is offering a grant for a clinical trial studying the effects of vitamin D supplementation on falls and gait speed in older adults. The six-year project aims to determine the optimal dosage and efficacy of vitamin D in preventing falls, considering various doses and baseline vitamin D levels. The study will also assess the impact of supplementation on gait speed as a secondary outcome. Applicants are encouraged to use innovative designs, such as dose-ranging and efficacy phases. Initial funds will support pilot studies for recruitment strategies and finalizing trial protocols.

Opportunity ID: 237318

Apply

General Information

Document Type::	Grants Notice
Funding Opportunity Number::	RFA-AG-14-001
Funding Opportunity Title::	Dose Response and Efficacy Studies on the Effects of Vitamin D Supplementation on Functional Outcomes in Elderly (U01)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.866 — Aging Research
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 1
Posted Date::	Jul 08, 2013
Last Updated Date::
Original Closing Date for Applications::	Sep 23, 2013
Current Closing Date for Applications::	Sep 23, 2013
Archive Date::	Oct 24, 2013
Estimated Total Program Funding::
Award Ceiling::	$
Award Floor::	$

Eligibility

Eligible Applicants::

County governments

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	The National Institute on Aging (NIA) invites applications for a clinical trial on effects of vitamin D supplementation on falls and gait speed in older individuals. During the six-year support period, the awardee will implement a randomized controlled trial with sufficient power to determine the doseresponse and efficacy of vitamin D supplementation in preventing falls, across a range of doses and baseline vitamin D levels. A measurement of effects of supplementation on gait speed should be proposed as a secondary outcome. Applicants are strongly encouraged to consider advanced, cost-efficient designs that include a dose-ranging phase followed by an efficacy phase for select doses (e.g., adaptive designs). The first nine months of the award will provide funds to conduct pilot studies to test recruitment strategies, determine the proportion of those screened who are both eligible and willing to be randomized, and finalize the study protocol, data collection forms and manual of procedures for the trial.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:	93.866
Competition ID:	FORMS-C
Competition Title:	Use for due dates after 9/24/2013
Opportunity Package ID:	PKG00180443
Opening Date:	Aug 23, 2013
Closing Date:	Sep 23, 2013
Agency Contact Information::	eRA Commons Help Desk
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3]