The National Institute on Aging offers a grant to establish a Center without Walls focused on developing PET radioligands to identify proteinopathies or pathological processes in Alzheimer’s disease related dementias. This grant supports activities such as in vitro ligand screening, medicinal chemistry, animal model testing, and first-in-human studies. The Center must have cores for administration, medicinal chemistry, clinical support, and a scientific governance structure. Projects within the Center should show synergistic progression towards ligand optimization and testing. This opportunity aims to address ADRD challenges identified in the National Plan to Address Alzheimer’s Disease update.
Opportunity ID: 311094
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-19-014 |
| Funding Opportunity Title: | Center without Walls for PET Ligand Development for Alzheimer’s disease related dementias (ADRDs) (U19 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 11, 2018 |
| Last Updated Date: | Dec 11, 2018 |
| Original Closing Date for Applications: | Feb 13, 2019 |
| Current Closing Date for Applications: | Feb 13, 2019 |
| Archive Date: | Mar 21, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education State governments Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) supports the development of PET radioligands that identify proteinopathies or pathological processes associated with the human biology of Alzheimer’s disease related dementias (ADRDs). Activities supported under this FOA include, but are not limited to the in vitro screening of existing ligands against human ADRD brain tissue, medicinal chemistry support for development of new compounds and improvement of existing ligand specificity and selectivity, initial screening of ligands in appropriate animal models, and radioligand formulation and first-in-human testing. The Center without Walls should encompass research that will move promising ligands through in vitro and in vivo optimization to first-in-human studies. Applications must include an administrative core, a medicinal chemistry core, a clinical core, a scientific governance structure, and a minimum of two research projects with milestone plans that address workflows for screening of existing and newly derived ligands against human ADRD tissue and appropriate animal models. Synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure. This FOA is in response to the Alzheimer’s Disease Related Dementias (ADRD) challenges outlined in the 2016 update to the National Plan to Address Alzheimer’s Disease. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-014.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00246802 | Jan 13, 2019 | Feb 13, 2019 | View |
Package 1
Mandatory forms
311094 RR_SF424_2_0-2.0.pdf
311094 PHS398_CoverPageSupplement_4_0-4.0.pdf
311094 RR_OtherProjectInfo_1_4-1.4.pdf
311094 PerformanceSite_2_0-2.0.pdf
311094 RR_KeyPersonExpanded_2_0-2.0.pdf
311094 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
311094 PHS_Additional_IndirectCosts-1.0.pdf
311094 PHS_AssignmentRequestForm_2_0-2.0.pdf
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