This grant from the National Institute on Aging aims to support interdisciplinary research to identify and validate molecular mechanisms contributing to tau toxicity in Frontotemporal Degeneration (FTD). The focus is on developing tools for FTD clinical trials. Applications must include core components such as research projects, a governance structure, resource cores, a data coordination core, and a human biology validation core. Projects must demonstrate synergy and the inability to be achieved outside of the Center structure. This grant opportunity aligns with the 2015 National Plan to Address Alzheimer’s Disease. Closing date for applications is May 10, 2016.
Opportunity ID: 281757
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-16-023 |
| Funding Opportunity Title: | Center without Walls for the Identification and Validation of Molecular Mechanisms Contributing to Tau Pathogenesis and Associated Neurodegeneration in Frontotemporal Degeneration (FTD) (U54) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 2 |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 24, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 10, 2016 |
| Current Closing Date for Applications: | May 10, 2016 |
| Archive Date: | Jun 10, 2016 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | $1,500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) County governments Private institutions of higher education Independent school districts Special district governments Public and State controlled institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this FOA is to support innovative interdisciplinary, multi-institute research that will lead to the identification and validation of molecular mechanisms relevant to human biology that contribute to tau toxicity associated with Frontotemporal Degeneration (FTD). It is anticipated that this research will also contribute to tool development that can be applied to target validation in FTD clinical trials.Applications must include an administrative core, a scientific governance structure, a minimum of three research projects with milestone plans, resource core(s) that support the basic research efforts of at least two proposed research projects, a data coordination core that will facilitate the distribution of data generated through the Center without Walls with the broad research community and a human biology validation core that will support the validation of mechanisms identified and resources developed under this FOA. Synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure. This FOA is in response to the Alzheimer’s Disease Related Dementias (ADRD) challenges outlined in the 2015 update to the National Plan to Address Alzheimer’s Disease. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-023.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | FORMS-D | PKG00222794 | May 07, 2016 | Jun 07, 2016 | View | |
| FORMS-C | FORMS-C | PKG00221162 | Apr 10, 2016 | Apr 15, 2016 | View |
Package 1
Mandatory forms
281757 RR_SF424_2_0-2.0.pdf
281757 PHS398_CoverPageSupplement_3_0-3.0.pdf
281757 RR_OtherProjectInfo_1_3-1.3.pdf
281757 PerformanceSite_2_0-2.0.pdf
281757 RR_KeyPersonExpanded_2_0-2.0.pdf
281757 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
281757 PHS_Additional_IndirectCosts-1.0.pdf
281757 PHS_AssignmentRequestForm-1.0.pdf
Package 2
Mandatory forms
281757 RR_SF424_2_0-2.0.pdf
281757 PHS398_CoverPageSupplement_2_0-2.0.pdf
281757 RR_KeyPersonExpanded_2_0-2.0.pdf
281757 RR_OtherProjectInfo_1_3-1.3.pdf
281757 PerformanceSite_2_0-2.0.pdf
281757 PHS398_ResearchPlan_2_0-2.0.pdf
Optional forms
281757 PHS_Additional_IndirectCosts-1.0.pdf
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