The National Institute on Aging is offering the Lewy Body Dementia Center Without Walls Grant for research on characterizing alpha-synuclein and amyloid-beta in human Lewy Body Dementia post-mortem brain tissue, identifying toxic subspecies, exploring mechanisms of toxicity, and investigating protein interactions. Projects must include 3 hypothesis-driven components focusing on human tissues, an administrative core, and relevant support cores. Applicants must plan on creating a public library of fully characterized alpha-synuclein and amyloid-beta subspecies in LBD. No clinical trials are permitted. Closing date for applications is January 4, 2019.
Opportunity ID: 310015
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-19-013 |
| Funding Opportunity Title: | Lewy Body Dementia Center Without Walls (CWOW) (U54 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 29, 2018 |
| Last Updated Date: | Oct 29, 2018 |
| Original Closing Date for Applications: | Jan 04, 2019 |
| Current Closing Date for Applications: | Jan 04, 2019 |
| Archive Date: | Feb 09, 2019 |
| Estimated Total Program Funding: | $3,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Special district governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) Private institutions of higher education County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA invites applications that will systematically and comprehensively characterize alpha-synuclein and amyloid-beta subspecies present in human Lewy Body Dementia (LBD) post-mortem brain tissue, identify toxic subspecies and potential mechanisms of toxicity, and characterize any interactions between the proteins that may contribute to increased toxicity and/or explain selective vulnerabilities of cells/circuits. Applications are required to include at least 3 hypothesis-driven projects that address these goals, an administrative core, and other cores as appropriate. Applicants will be expected to focus on the use of human tissues. All applications will be expected to include plans for developing a publicly-available library of fully characterized alpha-synuclein and amyloid-beta subspecies found in LBD. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-19-013.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00245946 | Dec 04, 2018 | Jan 04, 2019 | View |
Package 1
Mandatory forms
310015 RR_SF424_2_0-2.0.pdf
310015 PHS398_CoverPageSupplement_4_0-4.0.pdf
310015 RR_OtherProjectInfo_1_4-1.4.pdf
310015 PerformanceSite_2_0-2.0.pdf
310015 RR_KeyPersonExpanded_2_0-2.0.pdf
310015 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
310015 PHS_Additional_IndirectCosts-1.0.pdf
310015 PHS_AssignmentRequestForm_2_0-2.0.pdf
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