This grant is for catalyzing innovative research to elucidate the molecular landscape and functional implications of RNA modifications in brain aging and Alzheimer’s disease (AD) and AD-related dementias (ADRD). Specifically, this funding opportunity supports applications focused on uncovering novel mechanisms underlying RNA modification-mediated processes. These investigations should explore their impact on brain aging and the pathogenesis and progression of various dementias, including Lewy body, frontotemporal, vascular cognitive impairment/dementia, and mixed dementias. The ultimate goal is to identify crucial targets that can lead to the discovery of new biomarkers and the development of effective drugs for AD and related dementias, advancing our understanding and treatment of these complex neurological conditions.
Opportunity ID: 355757
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-25-022 |
| Funding Opportunity Title: | Deciphering the Impact of RNA Modifications on Brain Aging and AD/ADRD (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 31, 2024 |
| Last Updated Date: | Jul 31, 2024 |
| Original Closing Date for Applications: | Nov 01, 2024 |
| Current Closing Date for Applications: | Nov 01, 2024 |
| Archive Date: | Dec 07, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $125,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Private institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public and State controlled institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Native American tribal governments (Federally recognized) Small businesses State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to catalyze innovative research to elucidate the molecular landscape and functional implications of RNA modifications in brain aging and Alzheimer’s disease (AD) and AD-related dementias (ADRD). AD-related dementias include Lewy body dementia (LBD), frontotemporal dementia (FTD), vascular cognitive impairment/dementia (VCI/D), and mixed dementias. This NOFO supports applications focused on uncovering novel mechanisms underlying RNA modification-mediated processes and their impact on brain aging and the pathogenesis and progression of AD/ADRD. The ultimate goal is to identify targets for biomarker discovery and drug development for AD/ADRD. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-25-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 355757 Full Announcement-RFA-AG-25-022 -> RFA-AG-25-022-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00287544 | Oct 01, 2024 | Nov 01, 2024 | View |
Package 1
Mandatory forms
355757 RR_SF424_5_0-5.0.pdf
355757 PHS398_CoverPageSupplement_5_0-5.0.pdf
355757 RR_OtherProjectInfo_1_4-1.4.pdf
355757 PerformanceSite_4_0-4.0.pdf
355757 RR_KeyPersonExpanded_4_0-4.0.pdf
355757 PHS398_ResearchPlan_5_0-5.0.pdf
355757 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
355757 RR_Budget_3_0-3.0.pdf
355757 RR_SubawardBudget30_3_0-3.0.pdf
355757 PHS398_ModularBudget_1_2-1.2.pdf
355757 PHS_AssignmentRequestForm_3_0-3.0.pdf
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