The National Institute on Alcohol Abuse and Alcoholism is offering a grant to study sensitivity and tolerance mechanisms related to the development of alcohol use disorder. This grant aims to develop hypotheses on cellular, molecular, or network mechanisms affecting alcohol sensitivity and tolerance. It also seeks to create predictive models for tolerance development and progression to alcohol use disorder. This Phased Innovation (R21/R33) grant requires a clinical trial and allows for secondary data analysis or pilot studies in the R21 phase, with the opportunity to expand research in the R33 phase based on specific milestones. Deadline for application submission is on January 07, 2022.
Opportunity ID: 318261
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-19-311 |
| Funding Opportunity Title: | Mechanisms of Tolerance (R21/R33 – Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 10, 2019 |
| Last Updated Date: | Jul 10, 2019 |
| Original Closing Date for Applications: | Jan 07, 2022 |
| Current Closing Date for Applications: | Jan 07, 2022 |
| Archive Date: | Feb 12, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) focuses on sensitivity and tolerance mechanisms underlying the development of alcohol use disorder. The intent of this FOA is to: (1) develop hypotheses about cellular, molecular or network mechanisms that regulate sensitivity and tolerance to alcohol, and (2) develop quantitative models to predict the development of tolerance and the progression to alcohol use disorder. These objectives will be accomplished with a Phased Innovation (R21/R33) mechanism, clinical trial required, in which secondary data analysis or pilot studies can occur during the R21 phase, and research testing the hypotheses can be expanded in the R33 phase. The transition to the R33 phase will be determined by NIAAA program staff after evaluation of the achievement of specific milestones set for the R21 phase. Applicants interested in animal studies on the mechanisms of tolerance may consider FOA (PAR-18-659) or in the genetic basis of tolerance may consider FOA (PA-18-660). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-19-311.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00252830 | Sep 16, 2019 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00260079 | Sep 16, 2019 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270262 | Nov 16, 2021 | Jan 07, 2022 | View |
Package 1
Mandatory forms
318261 RR_SF424_2_0-2.0.pdf
318261 PHS398_CoverPageSupplement_4_0-4.0.pdf
318261 RR_OtherProjectInfo_1_4-1.4.pdf
318261 PerformanceSite_2_0-2.0.pdf
318261 RR_KeyPersonExpanded_2_0-2.0.pdf
318261 RR_Budget_1_4-1.4.pdf
318261 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
318261 RR_SubawardBudget30_1_4-1.4.pdf
318261 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
318261 RR_SF424_2_0-2.0.pdf
318261 PHS398_CoverPageSupplement_5_0-5.0.pdf
318261 RR_OtherProjectInfo_1_4-1.4.pdf
318261 PerformanceSite_2_0-2.0.pdf
318261 RR_KeyPersonExpanded_2_0-2.0.pdf
318261 RR_Budget_1_4-1.4.pdf
318261 PHS398_ResearchPlan_4_0-4.0.pdf
318261 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
318261 RR_SubawardBudget30_1_4-1.4.pdf
318261 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
318261 RR_SF424_5_0-5.0.pdf
318261 PHS398_CoverPageSupplement_5_0-5.0.pdf
318261 RR_OtherProjectInfo_1_4-1.4.pdf
318261 PerformanceSite_4_0-4.0.pdf
318261 RR_KeyPersonExpanded_4_0-4.0.pdf
318261 RR_Budget_3_0-3.0.pdf
318261 PHS398_ResearchPlan_4_0-4.0.pdf
318261 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
318261 RR_SubawardBudget30_3_0-3.0.pdf
318261 PHS_AssignmentRequestForm_3_0-3.0.pdf
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