The National Institutes of Health (NIH) is offering this grant to advance the development of next-generation human cell-derived microphysiological systems (MPS). This funding opportunity aims to support research applications focused on creating innovative MPS and associated assays that can replicate the intricate architectures and physiology of the human nervous system with significantly improved fidelity compared to existing technologies. This grant is specifically for projects designed to enable future, more accurate studies. These studies will explore various aspects of the complex nervous system, including its development, normal function, and aging processes, in both healthy conditions and disease states. The ultimate goal is to enhance our understanding of neurological health and disease.
Opportunity ID: 357016
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-199 |
| Funding Opportunity Title: | Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Jan 07, 2026 |
| Current Closing Date for Applications: | Jan 07, 2026 |
| Archive Date: | Feb 12, 2026 |
| Estimated Total Program Funding: | $200,000 |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal governments (Federally recognized) Independent school districts Small businesses Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-199.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357016 Full Announcement-PAR-25-199 -> PAR-25-199-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288554 | Jan 16, 2025 | Jan 07, 2026 | View |
Package 1
Mandatory forms
357016 RR_SF424_5_0-5.0.pdf
357016 PHS398_CoverPageSupplement_5_0-5.0.pdf
357016 RR_OtherProjectInfo_1_4-1.4.pdf
357016 PerformanceSite_4_0-4.0.pdf
357016 RR_KeyPersonExpanded_4_0-4.0.pdf
357016 PHS398_ResearchPlan_5_0-5.0.pdf
357016 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357016 RR_Budget_3_0-3.0.pdf
357016 RR_SubawardBudget30_3_0-3.0.pdf
357016 PHS398_ModularBudget_1_2-1.2.pdf
357016 PHS_AssignmentRequestForm_4_0-4.0.pdf
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