This grant from the National Institutes of Health aims to establish a Hemophilia A Analytical Cohort Research Program (HARP). This program will collaborate with clinical centers to recruit and follow an antenatal, neonatal, and pediatric cohort of severe Hemophilia A patients. HARP’s purpose is to create a unique, shareable biospecimen resource, thoroughly annotated with intergenerational clinical and demographic data, essential for future studies of Factor VIII immunogenicity. The program will also develop and implement protocols for hypothesis-driven research utilizing this rich data and biospecimen repository. HARP will provide comprehensive project coordination, data and biospecimen management, biostatistics, and laboratory expertise, ensuring the scientific development and expert conduct of research to establish this invaluable intergenerational cohort and resource for the scientific community.
Opportunity ID: 335632
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-22-004 |
| Funding Opportunity Title: | An Intergenerational Precision Medicine Research Program for the Study of Factor VIII Immunogenicity in Severe Hemophilia A: Hemophilia A Analytical Cohort Research Program (UG3/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.839 — Blood Diseases and Resources Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 09, 2021 |
| Last Updated Date: | Sep 09, 2021 |
| Original Closing Date for Applications: | Oct 19, 2021 |
| Current Closing Date for Applications: | Oct 19, 2021 |
| Archive Date: | Nov 24, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments State governments Independent school districts Special district governments County governments Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this FOA is to support applications that propose the establishment of a Hemophilia A Analytical Cohort Research Program (HARP) that will: 1) collaborate with an established consortium of clinical centers to support the recruitment, enrollment, and follow-up of an antenatal/ neonatal/ pediatric cohort in severe hemophilia A; 2) provide data management, laboratory, and biospecimen support necessary for the establishment of a unique and sharable biospecimen resource annotated with robust intergenerational clinical and demographic data to enable future studies of FVIII immunogenicity; and 3) develop and implement protocols and procedures to conduct hypothesis-driven research studies utilizing data and biospecimens from the antenatal/neonatal/pediatric cohort. The role of HARP is to provide overall project coordination, administration, data and biospecimen management, research protocols and procedures development and implementation, biostatistics/data analytics support; as well as laboratory (including multi-omics) and biorepository expertise for development of this unique intergenerational cohort and resource. HARP, in collaboration with the consortium of clinical centers, will lead the scientific development, pragmatic implementation, and expert conduct of the hypothesis-driven protocols that will permit the establishment of the severe Hemophilia A intergenerational cohort, utilization of some of the cohort longitudinal data and biospecimens, and establishment of a shareable resource for the scientific community. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-22-004.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268879 | Sep 19, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335632 RR_SF424_2_0-2.0.pdf
335632 PHS398_CoverPageSupplement_5_0-5.0.pdf
335632 RR_OtherProjectInfo_1_4-1.4.pdf
335632 PerformanceSite_2_0-2.0.pdf
335632 RR_KeyPersonExpanded_2_0-2.0.pdf
335632 RR_Budget10_1_4-1.4.pdf
335632 PHS398_ResearchPlan_4_0-4.0.pdf
335632 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335632 RR_SubawardBudget10_30_1_4-1.4.pdf
335632 PHS_AssignmentRequestForm_3_0-3.0.pdf
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