This National Institutes of Health grant supports clinical research on open- and closed-loop systems for physiological pancreatic hormone replacement in type 1 diabetes (T1D). It aims to test and improve their safety, reliability, and clinical efficacy. Research will address behavioral factors and evaluate systems in diverse, underserved patient populations to understand disparities. Technologies will also advance understanding of glucose regulation and T1D pathophysiology. Goals include improved metabolic control, reduced complications, and enhanced quality of life for patients and caregivers. Only human studies are considered.
Opportunity ID: 343331
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-22-020 |
| Funding Opportunity Title: | Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 01, 2022 |
| Last Updated Date: | Sep 01, 2022 |
| Original Closing Date for Applications: | Oct 26, 2023 |
| Current Closing Date for Applications: | Oct 26, 2023 |
| Archive Date: | Dec 01, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses State governments County governments City or township governments Special district governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this fundng opportunity announcemnt (FOA) is to promote clinical research using current and emerging technologies to address barriers that limit progress toward physiological pancreatic hormone replacement open- and closed-loop systems. It will support research to: 1) test and improve the safety, reliability, and clinical efficacy of these technologies; 2) address behavioral/psychosocial factors that play a role in the usability and acceptance of these systems and validation of measures that may be used as outcomes for the demonstration of efficacy and benefit; 3) test these technologies in subpopulations of patients not usually included in clinical trials who may benefit the most from their use; 4) test these technologies in individuals who are underserved or in low income and/or racial and ethnic minority groups, and better understand disparities in the use and adoption of these systems; and 5) use the technologies as tools to advance understanding of glucose regulation and its pathophysiology in patients with type 1 diabetes (T1D) including counter-regulation and impaired awareness of hypoglycemia. Research goals include improved metabolic control with decreased glycemic excursions, prevention of acute and chronic complications, and improved quality of life in patients with diabetes and their caregivers. Only human studies will be considered responsive to this FOA, applications involving animal or in vitro studies are not responsive to this FOA. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-22-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 343331 Full Announcement-RFA-DK-22-020 -> RFA-DK-22-020-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00276637 | Jan 28, 2023 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277864 | Jan 28, 2023 | Oct 26, 2023 | View |
Package 1
Mandatory forms
343331 RR_SF424_5_0-5.0.pdf
343331 PHS398_CoverPageSupplement_5_0-5.0.pdf
343331 RR_OtherProjectInfo_1_4-1.4.pdf
343331 PerformanceSite_4_0-4.0.pdf
343331 RR_KeyPersonExpanded_4_0-4.0.pdf
343331 PHS398_ResearchPlan_4_0-4.0.pdf
343331 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343331 RR_Budget_3_0-3.0.pdf
343331 RR_SubawardBudget30_3_0-3.0.pdf
343331 PHS398_ModularBudget_1_2-1.2.pdf
343331 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343331 RR_SF424_5_0-5.0.pdf
343331 PHS398_CoverPageSupplement_5_0-5.0.pdf
343331 RR_OtherProjectInfo_1_4-1.4.pdf
343331 PerformanceSite_4_0-4.0.pdf
343331 RR_KeyPersonExpanded_4_0-4.0.pdf
343331 PHS398_ResearchPlan_5_0-5.0.pdf
343331 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343331 RR_Budget_3_0-3.0.pdf
343331 RR_SubawardBudget30_3_0-3.0.pdf
343331 PHS398_ModularBudget_1_2-1.2.pdf
343331 PHS_AssignmentRequestForm_3_0-3.0.pdf
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