This grant is for advancing the structural understanding of protein species implicated in Alzheimer’s Disease Related Dementias (ADRDs). It aims to support detailed structural characterization using advanced techniques like cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) applied to proteins sourced from human tissues and cells. A crucial component of this funding opportunity is the development of innovative research tools and resources. These tools will be essential for further characterizing and validating the identified protein species, thereby contributing significantly to addressing the Alzheimer’s Disease Related Dementias challenges highlighted in the 2019 National Plan to Address Alzheimer’s Disease. The initiative seeks to build foundational knowledge to combat these debilitating conditions.
Opportunity ID: 341519
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-208 |
| Funding Opportunity Title: | Structural Biology of Alzheimer’s Disease Related Dementias (ADRDs) Proteinopathies (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 27, 2022 |
| Last Updated Date: | Jun 27, 2022 |
| Original Closing Date for Applications: | Oct 07, 2022 |
| Current Closing Date for Applications: | Oct 07, 2022 |
| Archive Date: | Nov 12, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Native American tribal governments (Federally recognized) City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts Special district governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of the FOA is to support the structural characterization of protein species associated with Alzheimer’s Disease Related Dementias (ADRDs) through the utilization of cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) of proteins expressed in human tissue and cell sources. Studies in response to this RFA should also include the development of research tools and resources to further characterize/validate the protein species. This FOA is in response to the Alzheimer’s Disease Related Dementias (ADRD) challenges outlined in the 2019 update to the National Plan to Address Alzheimer’s Disease. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-208.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00275280 | Sep 07, 2022 | Oct 07, 2022 | View |
Package 1
Mandatory forms
341519 RR_SF424_5_0-5.0.pdf
341519 PHS398_CoverPageSupplement_5_0-5.0.pdf
341519 RR_OtherProjectInfo_1_4-1.4.pdf
341519 PerformanceSite_4_0-4.0.pdf
341519 RR_KeyPersonExpanded_4_0-4.0.pdf
341519 PHS398_ResearchPlan_4_0-4.0.pdf
341519 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
341519 RR_Budget_3_0-3.0.pdf
341519 RR_SubawardBudget30_3_0-3.0.pdf
341519 PHS398_ModularBudget_1_2-1.2.pdf
341519 PHS_AssignmentRequestForm_3_0-3.0.pdf
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