The National Institutes of Health invites applicants for the R01 grant to delve into the metabolic processes that enhance anti-tumor immune responses, analyze the impact of tumor microenvironment on immune functions, and ultimately optimize cancer immunotherapy through metabolic reprogramming. The focus is on gaining a deeper insight into the metabolic mechanisms to boost the efficacy of immunotherapy. Application deadline is September 7, 2019.
Opportunity ID: 283620
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-16-228 |
| Funding Opportunity Title: | Metabolic Reprogramming to Improve Immunotherapy (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.396 — Cancer Biology Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 06, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2019 |
| Current Closing Date for Applications: | Sep 07, 2019 |
| Archive Date: | Oct 08, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Public housing authorities/Indian housing authorities Private institutions of higher education State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The overall goal of this funding opportunity announcement (FOA) is to encourage R01 grant applications to (a) generate a mechanistic understanding of the metabolic processes that support robust anti-tumor immune responses in vivo, (b) determine how the metabolic landscape of the tumor microenvironment affects immune effector functions, and (c) then use this information to manipulate (reprogram) the metabolic pathways used by the tumor, the immune response, or both to improve cancer immunotherapy. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-16-228.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or before January 24, 2018 | PKG00223347 | Sep 05, 2016 | Jan 24, 2018 | View | |
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00235794 | Nov 06, 2017 | Sep 07, 2019 | View |
Package 1
Mandatory forms
283620 RR_SF424_2_0-2.0.pdf
283620 PHS398_CoverPageSupplement_3_0-3.0.pdf
283620 RR_OtherProjectInfo_1_3-1.3.pdf
283620 PerformanceSite_2_0-2.0.pdf
283620 RR_KeyPersonExpanded_2_0-2.0.pdf
283620 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
283620 RR_Budget_1_3-1.3.pdf
283620 RR_SubawardBudget30_1_3-1.3.pdf
283620 PHS398_ModularBudget_1_2-1.2.pdf
283620 PHS_Inclusion_Enrollment_Report-1.0.pdf
283620 PHS_AssignmentRequestForm-1.0.pdf
Package 2
Mandatory forms
283620 RR_SF424_2_0-2.0.pdf
283620 PHS398_CoverPageSupplement_4_0-4.0.pdf
283620 RR_OtherProjectInfo_1_4-1.4.pdf
283620 PerformanceSite_2_0-2.0.pdf
283620 RR_KeyPersonExpanded_2_0-2.0.pdf
283620 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
283620 RR_Budget_1_4-1.4.pdf
283620 RR_SubawardBudget30_1_4-1.4.pdf
283620 PHS398_ModularBudget_1_2-1.2.pdf
283620 PHS_AssignmentRequestForm_2_0-2.0.pdf
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