NIH is offering this grant to advance the isolation and analysis of single extracellular vesicles (EVs) and their cargoes from human biofluids. The goal is to enhance understanding of the heterogeneity of exRNAs and their communication roles. By developing innovative technologies, this grant aims to characterize exRNA cargos associated with specific EV subpopulations based on cell of origin and target cell, ultimately accelerating exRNAs as therapeutics and diagnostics. Application deadline: Oct 23, 2018.
Opportunity ID: 308019
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-18-028 |
| Funding Opportunity Title: | Advancing Extracellular RNA (exRNA) Communication Research: Towards Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Oct 23, 2018 |
| Current Closing Date for Applications: | Oct 23, 2018 |
| Archive Date: | Nov 28, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) Small businesses City or township governments Independent school districts County governments Special district governments For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The ability to isolate and analyze single EVs and their cargoes from human biofluids would provide a unique opportunity to understand the cell or tissue from which their respective exRNAs originate (heterogeneity) and, importantly, add significant depth to our understanding of exRNA communication. The overarching goal of this Funding Opportunity Announcement (FOA) is to develop and demonstrate innovative technologies and reagents towards isolating single EVs and to characterize the exRNA cargos associated with specific EV subpopulations based on cell of origin and their intended target cell. Shedding light on the diversity of exRNAs carried by EVs will allow for a better understanding of the precise role of exRNAs as signaling molecules for both physiological and pathophysiological processes, ultimately accelerating development of exRNAs as therapeutics and diagnostics. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-18-028.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00244264 | Sep 23, 2018 | Oct 23, 2018 | View |
Package 1
Mandatory forms
308019 RR_SF424_2_0-2.0.pdf
308019 PHS398_CoverPageSupplement_4_0-4.0.pdf
308019 RR_OtherProjectInfo_1_4-1.4.pdf
308019 PerformanceSite_2_0-2.0.pdf
308019 RR_KeyPersonExpanded_2_0-2.0.pdf
308019 RR_Budget_1_4-1.4.pdf
308019 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
308019 RR_SubawardBudget30_1_4-1.4.pdf
308019 PHS_AssignmentRequestForm_2_0-2.0.pdf
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