This department is offering a grant to improve the reproducibility of human induced pluripotent stem cells (iPSCs) derivation, growth, and differentiation. The aim is to address the variability in reprogramming efficacy, genomic integrity, and developmental potential of iPSCs, ultimately standardizing and enhancing their utility in research and clinical applications. The grant seeks innovative approaches to optimize iPSC characteristics, culture conditions, and authentication processes, with the goal of advancing the field of iPSC research and facilitating their broader use in various scientific investigations. Applications for this grant should focus on developing reliable and cost-effective methods to ensure consistent iPSC behaviors and outcomes.
Opportunity ID: 316196
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-GM-19-001 |
| Funding Opportunity Title: | Methods to Improve Reproducibility of Human iPSC Derivation, Growth and Differentiation (SBIR) (R44 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 21, 2019 |
| Last Updated Date: | May 21, 2019 |
| Original Closing Date for Applications: | Jan 06, 2020 |
| Current Closing Date for Applications: | Jan 06, 2020 |
| Archive Date: | Feb 11, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $375,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Human induced pluripotent stem cells (iPSCs) have been used with great success to mimic the differentiation of a variety of tissues, understand early development and study human diseases. Despite approaches that have made the derivation, growth and differentiation of iPSCs more efficient, there remains significant variability in reprogramming efficacy, genomic integrity and developmental potential of iPSCs derived from a single fibroblast or tissue sample. Thus, iPSCs derived from the same sample may differ in their in vitro growth characteristics and their ability to re-differentiate into the desired tissue type. A variety of issues may affect derivation of the iPSCs and their growth, stability and differentiation, including the specific characteristics of the starting cell or tissue sample (e.g., age of donor, tissue type and anatomical location, physiological and disease state), the methods and protocols used to induce pluripotency (e.g., transcription factors, small molecules, cell fusion), the choice of growth factors and other culture conditions, method of storage of cell lines, etc. Further challenges include growing and maintaining sufficient quantities of iPSC lines in culture without changes in their properties, as well as the ability of multiple investigators to identify and authenticate iPSC lines as part of their research. This Funding Opportunity Announcement (FOA) will support SBIR projects to develop novel, reliable and cost-effective methods to standardize and increase the utility and reproducibility of iPSCs at all stages, from their derivation to their research and clinical applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-19-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00251179 | Dec 06, 2019 | Jan 06, 2020 | View |
Package 1
Mandatory forms
316196 RR_SF424_2_0-2.0.pdf
316196 PHS398_CoverPageSupplement_4_0-4.0.pdf
316196 RR_OtherProjectInfo_1_4-1.4.pdf
316196 PerformanceSite_2_0-2.0.pdf
316196 RR_KeyPersonExpanded_2_0-2.0.pdf
316196 RR_Budget_1_4-1.4.pdf
316196 PHS398_ResearchPlan_4_0-4.0.pdf
316196 SBIR_STTR_Information_1_2-1.2.pdf
Optional forms
316196 RR_SubawardBudget30_1_4-1.4.pdf
316196 PHS_AssignmentRequestForm_2_0-2.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
